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Promegestone

Known as: Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17beta)-, Promestone, 17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione 
A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and… 
National Institutes of Health

Related topics

Related topics

10 relations
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (3)

R-5020Surgestonetrimegestone

Papers overview

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2000
2000
Effects of progestins and relaxin on glycodelin gene expression in human endometrial cells.
Highly Cited
1998
Highly Cited
1998
Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.
One of the most abundant protein products of human secretory endometrium is glycodelin, a glycoprotein previously referred to as… 
Review
1993
Review
1993
Rapid non-genomic actions of progesterone stimulate Ca2+ influx and the acrosome reaction in human sperm.
Highly Cited
1992
Highly Cited
1992
Progesterone blocks cholesterol translocation from lysosomes.
1992
1992
Identification of an estrogen-binding protein in Pseudomonas aeruginosa
1989
1989
Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: characterization of an assay in breast cancer cell lines.
Progesterone receptors (PR) are the strongest predictors of response to hormone therapy in metastatic breast cancer, while PR and… 
Highly Cited
1988
Highly Cited
1988
Effects of progestins on sexual behaviour in castrated lizards (Cnemidophorus inornatus).
In many male vertebrates, androgens stimulate, while progesterone inhibits, sexual behaviour. Testicular androgens also control… 
Highly Cited
1982
Highly Cited
1982
Direct effects of sex steroids on prolactin release at the anterior pituitary level: interactions with dopamine, thyrotropin-releasing hormone, and isobutylmethylxanthine.
When present alone for 4 or 8 days, 5 alpha-dihydrotestosterone (DHT) or the pure progestin R5020 (17,21-dimethyl-19-nor-4,9… 
Highly Cited
1979
Highly Cited
1979
The relevance of hypothalamic and hyphophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the female rat.
Modifications in the concentration of progestinbinding sites (PR) in rat hypothalamus and pituitary, measured with [3H]R5020… 
Highly Cited
1976
Highly Cited
1976
Progestin receptors in human tissues: concentrations and binding kinetics.
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