Proline racemase
National Institutes of Health
Papers overview
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The origin of the catalytic proficiency of the cofactor-independent enzyme proline racemase (ProR) has been investigated by a…
Trypanosoma cruzi proline racemases (TcPRAC) are homodimeric enzymes that interconvert the L and D-enantiomers of proline. At…
The first eukaryotic proline racemase (PRAC), isolated from the human Trypanosoma cruzi pathogen, is a validated therapeutic…
Proline racemase catalyzes the interconversion of l- andd-proline enantiomers and has to date been described in only two species…
The results from the previous six papers are collated so as to allow the construction of the complete free energy profile for the…
The interconversion of L- and D-proline catalyzed by proline racemase has been studied. The entire time course of the approach to…
The isotope effects for the interconversion of L-proline and D-proline, catalyzed by proline racemase, have been determined in…
The fractionation factors of protons bound to the essential catalytic groups in proline racemase have been determined by…
Proline racemase exists in two states, one of which binds and isomerizes L-proline and the other of which binds and isomerizes D…
To test whether a reaction involving the making and/or breaking of two bonds at two sites is concerted (and proceeds through a…