Author pages are created from data sourced from our academic publisher partnerships and public sources.
Novel alkyl alkanethiolsulfonate sulfhydryl reagents. Modification of derivatives ofl-cysteine
A simple, general scheme for the synthesis of sulfhydryl-specific alkyl alkanethiolsulfonate (RSSO2R′) reagents where R′ is methyl, has been developed. Two new reagents, methyl… Expand
Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions.
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.
- Guangyi Wang, N. Boyle, +10 authors P. Cook
- Medicine, Chemistry
- Journal of medicinal chemistry
- 3 December 2004
In search of active nucleoside 5'-triphosphate mimics, we have synthesized a series of AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well… Expand
 Novel sulfhydryl reagents
Publisher Summary This chapter focuses on sulfhydryl reagents that have been categorized as blocking and labeling groups, reporter groups, cross-linking groups, and affinity labeling groups. Most of… Expand
Targeted chemical nucleases
The design of functional molecules has been an active area of research in chemistry and molecular biology during the past decade, encompassing topics such as host-guest chemistry, ribozymes,… Expand
Combinatorial Screening and Rational Optimization for Hybridization to Folded Hepatitis C Virus RNA of Oligonucleotides with Biological Antisense Activity*
- W. Lima, V. Brown-Driver, M. Fox, R. Hanecak, T. W. Bruice
- Biology, Medicine
- The Journal of Biological Chemistry
- 3 January 1997
We describe our initial application of a biochemical strategy, comprising combinatorial screening and rational optimization, which directly identifies oligonucleotides with maximum affinity (per unit… Expand
Targeted Chemical Nucleases
Pseudo--half-knot formation with RNA.
A pseudo--half-knot can be formed by binding an oligonucleotide asymmetrically to an RNA hairpin loop. This binding motif was used to target the human immunodeficiency virus TAR element, an important… Expand
Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA.
We have explored the use of short (10-mer), fully sequence-randomized oligonucleotide libraries for affinity-based screening in solution for energetically preferred sites of hybridization of a model… Expand