T. W. Bruice

Publications29
h-index15
Citations1,087
Highly Influential Citations15
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Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions.
Novel alkyl alkanethiolsulfonate sulfhydryl reagents. Modification of derivatives ofl-cysteine
A simple, general scheme for the synthesis of sulfhydryl-specific alkyl alkanethiolsulfonate (RSSO2R′) reagents where R′ is methyl, has been developed. Two new reagents, methyl…
Novel sulfhydryl reagents.
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.
TLDR
For the first time, a highly active and stable nucleoside triphosphate mimic has been identified, which is potentially useful as a new type of antiviral drug.
[40] Novel sulfhydryl reagents
Publisher Summary This chapter focuses on sulfhydryl reagents that have been categorized as blocking and labeling groups, reporter groups, cross-linking groups, and affinity labeling groups. Most of…
Targeted chemical nucleases
The design of functional molecules has been an active area of research in chemistry and molecular biology during the past decade, encompassing topics such as host-guest chemistry, ribozymes,…
Combinatorial Screening and Rational Optimization for Hybridization to Folded Hepatitis C Virus RNA of Oligonucleotides with Biological Antisense Activity*
TLDR
The affinities of DNA and uniform 2′-F-, P=S-substituted 10-20-mer oligonucleotide complements for the best hybridization site closely corresponded to antisense mechanism inhibition activities in an in vitro translation assay and in a human cell-based HCV core protein expression assay, respectively.
Targeted Chemical Nucleases
Pseudo--half-knot formation with RNA.
TLDR
A pseudo--half-knot can be formed by binding an oligonucleotide asymmetrically to an RNA hairpin loop and this general binding motif may be used to disrupt the structure of regulatory RNA hairpins.
Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA.
TLDR
The use of short (10-mer), fully sequence-randomized oligonucleotide libraries for affinity-based screening in solution for energetically preferred sites of hybridization of a model 47-nucleotide mutant Ha-ras mRNA stem-loop fragment suggested that there was the emergence of multiple, linked binding interactions.
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