Procarbazine

Known as: p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide, 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide, p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide 
A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated… (More)
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND Grade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration and premature death… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Temozolomide (TMZ) is an alkylating agent licensed for treatment of high-grade glioma (HGG). No prospective comparison… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Faced with unsatisfactory results of treatment for advanced Hodgkin's disease, we investigated three combinations of… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To evaluate whether two commonly used newer platinum-based regimens offer any advantage over vinorelbine-cisplatin… (More)
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Highly Cited
2000
Highly Cited
2000
A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent… (More)
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Highly Cited
1990
Highly Cited
1990
Data from Northern California Oncology Group protocol 6G61, which was closed in February 1983, were reanalyzed in December 1988… (More)
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Highly Cited
1983
Highly Cited
1983
Within 3 weeks of definitive surgery, 609 patients with histologically demonstrated, supratentorial malignant glioma were… (More)
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