Position Effect Variegation

Sequences proximal to transgene integration sites are able to deregulate transgene expression resulting in complex position… (More)

Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila… (More)

Variations in compaction of chromosomal material of the rearrangements Dp(1;f) 1337, Dp(1;f) R, Dp(1;1)pn2b, and T(1;4)w m258-21… (More)

Terminal deletions of a Drosophila minichromosome (Dp(1;f)1187) dramatically increase the position effect variegation (PEV) of a… (More)

Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration… (More)

A euchromatic gene placed in the vicinity of heterochromatin by a chromosomal rearrangement generally exhibits position effect… (More)

Chromatin structure at Schizosaccharomyces pombe centromeres is unusual. The insertion of the ura4 gene within these centromeres… (More)

Most variegating position effects are a consequence of placing a euchromatic gene adjacent to alpha-heterochromatin. In such… (More)

Twelve dominant enhancers of position effect variegation, representing four loci on the second and third chromosomes of… (More)

The histone genes of wild-type Drosophila melanogaster are reiterated 100-150 times per haploid genome and are located in the… (More)