Position Effect Variegation

Genes normally resident in euchromatic domains are silenced when packaged into heterochromatin, as exemplified in Drosophila… Expand

mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect… Expand

Publisher Summary This chapter describes that the problems relating to the organization of heterochromatin are prominent in the… Expand

Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration… Expand

A euchromatic gene placed in the vicinity of heterochromatin by a chromosomal rearrangement generally exhibits position effect… Expand

Heterochromatin is both necessary for the expression of heterochromatic genes and inhibitory for the expression of euchromatic… Expand

Chromatin structure at Schizosaccharomyces pombe centromeres is unusual. The insertion of the ura4 gene within these centromeres… Expand

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such… Expand

Position effect variegation results from chromosome rearrangements which translocate euchromatic genes close to the… Expand

Twelve dominant enhancers of position effect variegation, representing four loci on the second and third chromosomes of… Expand