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Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
It is demonstrated that this silencing is dependent on the RNA interference machinery, using tandem mini-white arrays and white transgenes in heterochromatin to show loss of silencing as a result of mutations in piwi, aubergine, or spindle-E (homeless), which encode RNAi components.
RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila.
MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair
It is proposed that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair, and greatly decreased DNA double-strand break repair by both NHEJ and homologous recombination.
RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements
Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits.
Because the majority of dosage-dependent regulators act negatively, this property can account for the up-regulation of genes in monosomics and hemizygous sex chromosomes to achieve dosage compensation.
Cosuppression in Drosophila: Gene Silencing of Alcohol dehydrogenase by white-Adh Transgenes Is Polycomb Dependent
Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes.
MicroRNAs – micro in size but macro in function
The mechanism of miRNA biogenesis and the role of miRNAs in human health and disease are focused on.
Role of the male specific lethal (msl) genes in modifying the effects of sex chromosomal dosage in Drosophila.
It is suggested that sequestration of the MSL proteins occurs in males to nullify on the autosomes and maintain on the X, an inverse effect produced by negatively acting dosage-dependent regulatory genes as a consequence of the evolution of the X/Y sex chromosomal system.
Misregulation of Sex-Lethal and Disruption of Male-Specific Lethal Complex Localization in Drosophila Species Hybrids
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans, where sex-lethal (Sxl) is misregulated in these hybrids.