Polygenic Inheritance

Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide… Expand

In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions… Expand

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci… Expand

Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal… Expand

Age-related hearing loss (AHL) in common inbred mouse strains is a genetically complex quantitative trait. We found a synonymous… Expand

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro… Expand

Genotype-environment interactions may be a potent force maintaining genetic variation in quantitative traits in natural… Expand

Breeders have traditionally improved plant varieties by selecting on the basis of phenotype. Now restriction fragment length… Expand

The joint evolution of female mating preferences and secondary sexual characters of males is modeled for polygamous species in… Expand

In discussions of the major features of evolution, Simpson (1953) applied population genetic models to the interpretation of the… Expand