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Polycomb Repressive Complex 2

Known as: Polycomb Repressive Complex 2 [Chemical/Ingredient] 
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE… 
National Institutes of Health

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Related topics

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In BloodProcess of secretionagonistsantagonists & inhibitors

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Jarid2 protein, mousePhc2 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Polycomb repressive complex 2 in an autoinhibited state
Polycomb-group proteins control many fundamental biological processes, such as anatomical development in mammals and… 
2017
2017
Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation
In ∼50% of prostate cancers, chromosomal rearrangements cause the fusion of the promoter and 5′-UTR of the androgen-regulated… 
2016
2016
An allosteric PRC 2 inhibitor targeting the H 3 K 27 me 3 binding pocket of EED
Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Hailong Zhang, Maya Zhang, Jeff Zhang, Zhengtian Yu, Ling Li, Lin Teng… 
2014
2014
The Polycomb Protein Ezh2 Impacts on Induced Pluripotent Stem Cell Generation
Reprogramming of somatic cells toward pluripotency involves extensive chromatin reorganization and changes in gene expression… 
2014
2014
Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome
The correlation between DNA methylation and a subset of histone post-translational modifications (positive and negative) has… 
2013
2013
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.
Deregulation of polycomb group complexes polycomb repressive complex 1 (PRC1) and 2 (PRC2) is associated with human cancers… 
2012
2012
A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.
2011
2011
An E3 ligase complex regulates SET-domain polycomb group protein activity in Arabidopsis thaliana
Transcriptional repression via methylation of histone H3 lysine 27 (H3K27) by the polycomb repressive complex 2 (PRC2) is… 
2011
2011
16-hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells.
Review
2010
Review
2010
Viral-encoded enzymes that target host chromatin functions.
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