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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.
- J. C. Eissenberg, T. C. James, D. Foster-Hartnett, T. Hartnett, V. Ngan, S. Elgin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 1990
We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of… Expand
The COMPASS Family of H3K4 Methylases in Drosophila
- Man Mohan, H. Herz, +6 authors A. Shilatifard
- Biology, Medicine
- Molecular and Cellular Biology
- 29 August 2011
ABSTRACT Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human MLL1 and… Expand
The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.
- J. C. Eissenberg, G. Morris, G. Reuter, T. Hartnett
- Biology, Medicine
- Genetics
- 1 June 1992
Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to… Expand
Specificity of the HP1 chromo domain for the methylated N‐terminus of histone H3
- S. A. Jacobs, S. Taverna, +5 authors S. Khorasanizadeh
- Biology, Medicine
- The EMBO journal
- 17 September 2001
Recent studies show that heterochromatin‐associated protein‐1 (HP1) recognizes a ‘histone code’ involving methylated Lys9 (methyl‐K9) in histone H3. Using in situ immunofluorescence, we demonstrate… Expand
The HP1 protein family: getting a grip on chromatin.
- J. C. Eissenberg, S. Elgin
- Medicine, Biology
- Current opinion in genetics & development
- 1 April 2000
HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family… Expand
Functional analysis of the chromo domain of HP1.
- J. Platero, T. Hartnett, J. C. Eissenberg
- Biology, Medicine
- The EMBO journal
- 1 August 1995
Heterochromatin protein 1 (HP1) is a non‐histone chromosomal protein in Drosophila with dosage‐dependent effects on heterochromatin‐mediated gene silencing. An evolutionarily conserved amino acid… Expand
Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila.
- T. C. James, J. C. Eissenberg, C. Craig, V. Dietrich, A. Hobson, S. Elgin
- Biology, Medicine
- European journal of cell biology
- 1 October 1989
We have previously reported the identification of a nonhistone chromosomal protein (nhcp-19; now called HP1) preferentially associated with the heterochromatin of Drosophila melanogaster. A detailed… Expand
Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon.
- J. C. Eissenberg, R. Ayyagari, X. Gomes, P. Burgers
- Biology, Medicine
- Molecular and cellular biology
- 1 November 1997
The importance of the interdomain connector loop and of the carboxy-terminal domain of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) for functional interaction with DNA… Expand
Histone H3 lysine 4 (H3K4) methylation in development and differentiation.
- J. C. Eissenberg, A. Shilatifard
- Biology, Medicine
- Developmental biology
- 15 March 2010
Covalent modification of histones on chromatin is a dynamic mechanism by which various nuclear processes are regulated. Methylation of histone H3 on lysine 4 (H3K4) implemented by the macromolecular… Expand
Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.
- T. Zhao, T. Heyduk, C. Allis, J. C. Eissenberg
- Biology, Medicine
- The Journal of biological chemistry
- 8 September 2000
Heterochromatin protein 1 (HP1) is a nonhistone chromosomal protein primarily associated with the pericentric heterochromatin and telomeres in Drosophila. The molecular mechanism by which HP1… Expand