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Phosphoribosylpyrophosphate synthetase

National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase… Expand
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Highly Cited
1995
Highly Cited
1995
The genetic and functional basis of phosphoribosylpyrophosphate synthetase (PRS) superactivity associated with purine nucleotide… Expand
Highly Cited
1980
Highly Cited
1980
An inherited, structurally abnormal and superactive form of the enzyme 5-phosphoribosyl 1-pyrophosphate (PP-ribose-P) synthetase… Expand
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Highly Cited
1975
Highly Cited
1975
We have reported previously two siblings with gout and uric acid lithiasis associated with excessive purine production. In the… Expand
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Highly Cited
1973
Highly Cited
1973
Abstract A mutant phosphoribosylpyrophosphate synthetase was found in the erythrocytes of a gouty subject with excessive purine… Expand
Highly Cited
1973
Highly Cited
1973
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate… Expand
Highly Cited
1973
Highly Cited
1973
Abstract Phosphoribosylpyrophosphate (PRPP) synthetase participates in the biosynthesis in bacteria of purine nucleotides… Expand
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Highly Cited
1972
Highly Cited
1972
Abstract Human PP-ribose-P synthetase, partially purified from erythrocytes, was found to have Michaelis constants for ribose-5-P… Expand
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Highly Cited
1971
Highly Cited
1971
Abstract Phosphoribosylpyrophosphate (PP-ribose-P) synthetase was found to be distributed in all human tissues assayed and has… Expand
Highly Cited
1969
Highly Cited
1969
  • R. Switzer
  • The Journal of biological chemistry
  • 1969
  • Corpus ID: 26391273
Abstract A procedure is described for a 450-fold purification of 5-phosphoribosyl α-1-pyrophosphate (PRPP) synthetase from cells… Expand