Phosphoribosylpyrophosphate synthetase
National Institutes of Health
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1. The synthesis of nicotinamide-adenine dinucleotide from nicotinamide and nicotinic acid was compared over different time…
Complementary DNA clones for phosphoribosylpyrophosphate synthetase subunits I and II (PRS I and PRS II) were used to determine…
Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP…
Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster…
The activity of phosphoribosylpyrophosphate synthetase and the rate of phosphoribosylpyrophosphate accumulation are significantly…
Among affected members of a family (B. family) with excessive purine production and gout, activity of phosphoribosylpyrophosphate…
A clone of cells in which the regulation of purine metabolism is genetically altered was selected and isolated from chemically…
Abstract Human PP-ribose-P synthetase, partially purified from erythrocytes, was found to have Michaelis constants for ribose-5-P…
Abstract An analysis of the kinetic mechanism of phosphoribosylpyrophosphate (PRPP) synthetase has been carried out with highly…
Abstract A procedure is described for a 450-fold purification of 5-phosphoribosyl α-1-pyrophosphate (PRPP) synthetase from cells…