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Phosphoribosylpyrophosphate synthetase

National Institutes of Health

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2 relations
Phosphoribosylpyrophosphate synthetase:CCnt:Pt:Fibroblasts:QnPhosphoribosylpyrophosphate synthetase:CCnt:Pt:RBC:Qn

Papers overview

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Highly Cited
2007
Highly Cited
2007
Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site.
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase… Expand
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Highly Cited
1995
Highly Cited
1995
The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity.
The genetic and functional basis of phosphoribosylpyrophosphate synthetase (PRS) superactivity associated with purine nucleotide… Expand
Highly Cited
1980
Highly Cited
1980
Variant human phosphoribosylpyrophosphate synthetase altered in regulatory and catalytic functions.
An inherited, structurally abnormal and superactive form of the enzyme 5-phosphoribosyl 1-pyrophosphate (PP-ribose-P) synthetase… Expand
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Highly Cited
1975
Highly Cited
1975
Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts.
We have reported previously two siblings with gout and uric acid lithiasis associated with excessive purine production. In the… Expand
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Highly Cited
1973
Highly Cited
1973
Human erythrocyte phosphoribosylpyrophosphate synthetase mutationally altered in regulatory properties.
Abstract A mutant phosphoribosylpyrophosphate synthetase was found in the erythrocytes of a gouty subject with excessive purine… Expand
Highly Cited
1973
Highly Cited
1973
Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity
In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate… Expand
Highly Cited
1973
Highly Cited
1973
Regulation and mechanism of phosphoribosylpyrophosphate synthetase. V. Inhibition by end products and regulation by adenosine diphosphate.
Abstract Phosphoribosylpyrophosphate (PRPP) synthetase participates in the biosynthesis in bacteria of purine nucleotides… Expand
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Highly Cited
1972
Highly Cited
1972
Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition.
Abstract Human PP-ribose-P synthetase, partially purified from erythrocytes, was found to have Michaelis constants for ribose-5-P… Expand
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Highly Cited
1971
Highly Cited
1971
Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties.
Abstract Phosphoribosylpyrophosphate (PP-ribose-P) synthetase was found to be distributed in all human tissues assayed and has… Expand
Highly Cited
1969
Highly Cited
1969
Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium.
  • R. Switzer
  • The Journal of biological chemistry
  • 1969
    • Corpus ID: 26391273
Abstract A procedure is described for a 450-fold purification of 5-phosphoribosyl α-1-pyrophosphate (PRPP) synthetase from cells… Expand
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