Phosphodiesterase Type 4

Known as: cAMP-Specific Phosphodiesterase Type 4, 3',5'-Cyclic-AMP 5'-Nucleotidohydrolase Type 4, cAMP-Specific Phosphodiesterase 4 
A family of phosphodiesterases that hydrolyze cyclic AMP to form AMP. This enzyme family is the primary cyclic nucleotide phosphodiesterase expressed… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2007
Review
2007
Cyclic AMP regulates a vast number of distinct events in all cells. Early studies established that its hydrolysis by cyclic… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Early developmental perturbations have been linked to adult-onset prostate pathology, including excessive exposure to estrogenic… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • figure 3
Is this relevant?
Review
2006
Review
2006
Plant flavonoids are widely distributed polyphenolic compounds of the human diet. They consist of six major classes based on… (More)
Is this relevant?
Review
2005
Review
2005
Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The cyclic AMP-specific phosphodiesterase (PDE4) isoform PDE4A5 interacted with the immunophilin XAP2 in a yeast two-hybrid assay… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Spatiotemporal regulation of protein kinase A (PKA) activity involves the manipulation of compartmentalized cAMP pools. Now we… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common, progressive respiratory disease that causes great morbidity… (More)
Is this relevant?