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Phosphodiesterase Type 4

Known as: cAMP-Specific Phosphodiesterase Type 4, 3',5'-Cyclic-AMP 5'-Nucleotidohydrolase Type 4, cAMP-Specific Phosphodiesterase 4 
A family of phosphodiesterases that hydrolyze cyclic AMP to form AMP. This enzyme family is the primary cyclic nucleotide phosphodiesterase expressed… 
National Institutes of Health

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Esterases

Papers overview

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Highly Cited
2008
Highly Cited
2008
Antipsychotic-Like Properties of Phosphodiesterase 4 Inhibitors: Evaluation of 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with Auditory Event-Related Potentials and Prepulse…
Antipsychotic medications function through antagonism of D2 dopamine receptors. Blockade of D2 receptors causes an increase in… 
2007
2007
Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.
The pineal gland is a photoneuroendocrine transducer that influences circadian and circannual dynamics of many physiological… 
Review
2006
Review
2006
Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling.
2006
2006
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Specificity of cAMP signalling pathways has shown that the intracellular targeting of the individual components confers a three… 
Highly Cited
2003
Highly Cited
2003
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel…
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to… 
2002
2002
Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.
2002
2002
Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3',5'-monophosphate-dependent pathway.
Intrauterine infections are important etiological factors of preterm labor. They trigger an increase in proinflammatory cytokines… 
Highly Cited
2001
Highly Cited
2001
Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues.
A number of 6-(3,4-dimethoxyphenyl)-4,5-dihydro-2H-pyridazin-3-ones and a novel series of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1… 
1997
1997
Chelerythrine, a protein kinase C inhibitor, interacts with cyclic nucleotide phosphodiesterases.
1997
1997
Src tyrosine kinase activity in rat thecal–interstitial cells and mouse TM3 Leydig cells is positively associated with cAMP-specific phosphodiesterase activity
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