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Phosphodiesterase Type 4
Known as:
cAMP-Specific Phosphodiesterase Type 4
, 3',5'-Cyclic-AMP 5'-Nucleotidohydrolase Type 4
, cAMP-Specific Phosphodiesterase 4
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A family of phosphodiesterases that hydrolyze cyclic AMP to form AMP. This enzyme family is the primary cyclic nucleotide phosphodiesterase expressed…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Monitoring local pulmonary cAMP levels: combining precision cut lung slice (PCLS) and fluorescence resonance energy transfer (FRET) technologies in mice
Hao-Xiao Zuo
,
Wilfred J. Poppinga
,
E. Zeisberg
,
V. Nikolaev
,
M. Schmidt
2016
Corpus ID: 78653374
RATIONALE Cyclic AMP (cAMP) is one of the most important second messengers and is involved as a target for the therapy of chronic…
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2014
2014
The neuroprotective effect of caffeic acid phenethyl ester on global ischemia-reperfusion injury in rat brains.
M. Altuğ
,
Ismet Melek
,
S. Erdogan
,
V. Duzguner
,
Atakan Öztürk
,
A. Küçükgül
2014
Corpus ID: 49570433
The aim of this study was to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE) on phosphodiesterase…
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2013
2013
Pharmaceutical composition comprising a PDE4 inhibitor and PI3deruta inhibitor or dual PI3δ-γ kinase inhibitor
スループ・クマール・ヴェンカタ・サティア・ヴァッカランカ
,
シュリカント・ヴィスワナダ
2013
Corpus ID: 86715257
The present invention, autoimmune, respiratory resistance, and / or inflammatory disease or disorder (e.g., psoriasis, rheumatoid…
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2007
2007
UK-500,001, a potent selective inhibitor of phosphodiesterase type 4 (PDE4) designed for inhaled delivery, inhibits TNF-a, MIP-1b and LTB4 released from native blood cells.
M. Trevethick
,
K. Banner
,
+9 authors
M. Yeadon
2007
Corpus ID: 100452513
2006
2006
Adrenergic Receptor 2 β Locally Confined-Adrenergic but 1 β Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching
M. Bünemann
,
E. Schmitteckert
,
M. Lohse
,
S. Engelhardt
2006
Corpus ID: 11991142
1and 2-adrenergic receptors ( ARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the…
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2004
2004
Suppression of superoxide production in human neutrophils through inhibition of PDE4 : an implication for a role of cAMP in anti-ulcer action of irsogladine
M. Oka
2004
Corpus ID: 87708819
2004
2004
Ｎ-알킬-히드록삼산-이소인돌릴 화합물 및 그의 제약학적용도
맨 혼-와
,
뮬러 조지더블유.
2004
Corpus ID: 188383405
본 발명은 신규 N-알킬-히드록삼산-이소인돌릴 화합물, 이 화합물의 제약 조성물, 및 포유동물에서 상기 화합물 및 조성물을 사용하여 다양한 질환 및 장애, 예를 들어, PDE4…
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2002
2002
The Effect of Phosphodiesterase Type 4 and 5 Inhibitors on Ileal Motor Function of the Guinea Pig
Hyojin Park
,
S. Choi
,
Yong-Ho Lee
,
J. Lim
,
Sang-In Lee
,
I. Park
2002
Corpus ID: 77276527
Background/Aims: Intracellular cAMP or cGMP is degraded by cyclic nucleotide phosphodiesterase (PDE). We hypothesized that PDE…
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2000
2000
The intracellular targeting and regulation of PDE4 cyclic AMP-specific phosphodiesterase enzymes
A. Peden
2000
Corpus ID: 201157153
Cyclic adenosine 5': 3' monophosphate (cAMP) is a ubiquitous second messenger in cells which transduces the action of a wide…
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Review
1998
Review
1998
PDE4 inhibitors 1998
P. Norman
1998
Corpus ID: 57459593
The search for novel phosphodiesterase Type 4 (PDE4) inhibitors is currently one of the most active fields within the…
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