FAQ

Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A

Known as: Phosphatidylinositol-Glycan Biosynthesis Class A Protein, Phosphatidylinositol Glycan Anchor Biosynthesis, Class A, GlcNAc-PI Synthesis Protein 
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (484 aa, ~54 kDa) is encoded by the human PIGA gene. This protein is involved in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
05101519932017

Related topics

Related topics

10 relations
Carbohydrate MetabolismEndoplasmic ReticulumEnzyme GeneGlycosyltransferase Gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit A
Endoplasmic Reticulum
Integral Membrane Proteins
Carbohydrate Metabolism
Paroxysmal nocturnal hemoglobinuria
Protein Glycosylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
The spectrum of PIG-A gene mutations in aplastic anemia/paroxysmal nocturnal hemoglobinuria (AA/PNH): a high incidence of multiple mutations and evidence of a mutational hot spot.
Paroxysmal nocturnal hemoglobinuria (PNH) may arise during long-term follow- up of aplastic anemia (AA), and many AA patients… (More)
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Highly Cited
1999
Highly Cited
1999
Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.
In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A gene give rise to clonal populations of red… (More)
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1998
1998
The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by chronic hemolysis with… (More)
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1997
1997
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder resulting from mutations in an X-linked… (More)
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1996
1996
PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum.
Many eukaryotic cell surface proteins are bound to the membrane via a glycosylphosphatidylinositol (GPI) anchor. Assembly of the… (More)
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1995
1995
Mutations in the PIG-A gene causing paroxysmal nocturnal hemoglobinuria are mainly of the frameshift type.
Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia associated with somatic mutations in the X-linked gene PIG-A… (More)
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1995
1995
The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis.
The protein encoded by the yeast gene SPT14 shows high sequence similarity to the human protein, PIG-A, whose loss of activity is… (More)
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1995
1995
Heterogeneous PIG-A mutations in different cell lineages in paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal defect of hematopoietic stem cells in which affected cells are… (More)
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Highly Cited
1994
Highly Cited
1994
Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.
Paroxysmal nocturnal haemoglobinuria (PNH), an acquired clonal blood disorder, is caused by the absence of glycosyl… (More)
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Highly Cited
1993
Highly Cited
1993
The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.
The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of… (More)
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