Phenformin

Known as: Imidodicarbonimidic diamide, N-(2-phenylethyl)-, Phenforminum, Fenformina 
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Metformin, a first-line diabetes drug linked to cancer prevention in retrospective clinical analyses, inhibits cellular… (More)
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Highly Cited
2013
Highly Cited
2013
The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC). LKB1 is… (More)
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Highly Cited
2013
Highly Cited
2013
Biguanides, such as the diabetes therapeutics metformin and phenformin, have demonstrated antitumor activity both in vitro and in… (More)
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Highly Cited
2013
Highly Cited
2013
Glucose production by the liver is essential for providing a substrate for the brain during fasting. The inability of insulin to… (More)
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Highly Cited
2010
Highly Cited
2010
Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing to its central role in controlling cell… (More)
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Highly Cited
2005
Highly Cited
2005
Recent studies indicate that the LKB1 tumour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP… (More)
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Highly Cited
2004
Highly Cited
2004
Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes… (More)
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Highly Cited
2004
Highly Cited
2004
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master… (More)
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Review
2002
Review
2002
Insulin resistance contributes greatly to development of cardiovascular disease in patients with the metabolic syndrome and its… (More)
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