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Phenformin

Known as: Imidodicarbonimidic diamide, N-(2-phenylethyl)-, Phenforminum, Fenformina 
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (3)

4-hydroxyphenforminphenethylguanidinetolbutaphen
HypoglycemiaIn BloodPhenformin Hydrochlorideagonists

Broader (2)

Hypoglycemic Agentsorganic nitrogen compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic systems.
Administration of 100 mg phenformin combined with 8 mg ethyloestrenol for 30 days to 9 healthy volunteers raised the fibrinolytic… 
1977
1977
Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics
SummaryTwelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of… 
1975
1975
Effect of Phenformin on Gluconeogenesis from Lactate and Intracellular pH in the Isolated Perfused Guinea Pig Liver
Gluconeogenesis from lactate and hepatic cell pH (pHi) were measured in the isolated perfused livers of starved guinea pigs in… 
1975
1975
Lactic Acidosis Associated with Phenformin Therapy: Evidence that Inhibited Lactate Oxidation is the Causative Factor
Using uniformly labeled 14C L-lactate, we have studied the turnover and oxidation of lactic acid in a patient who presented with… 
1972
1972
Hyperlactataemia in Phenformin-treated Diabetics
Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous… 
1970
1970
Fatal self-poisoning with phenformin.
A 44-year-old housewife, who in 1954 developed tuberculous pericarditis treated with chemotherapy and pericardectomy, had been… 
Highly Cited
1963
Highly Cited
1963
The Effects of Guanidine and Alkylguanidines on the Energy Transfer Reactions of Mitochondria
Considerable attention has been focused on the biological activity of guanidine derivatives from two main directions. Ever since… 
1963
1963
LACTATE ACIDOSIS ASSOCIATED WITH PHENFORMIN THERAPY AND LOCALIZED TISSUE HYPOXIA. REPORT OF A CASE TREATED BY HEMODIALYSIS.
Excerpt The oral hypoglycemic agent phenformin (N1-β-phenethylbiguanide hydrochloride (DBI⌖*)) was greeted with hopeful… 
Review
1960
Review
1960
Tissue Distribution of C14-labeled Beta-phenethylbiguanide
Since the original report by Ungar et al. on the hypoglycemic action of phenethylbiguanide, now more commonly known as DBI, the… 
1959
1959
Secondary failure of response to tolbutamide treatment.
A group of 200 patients with diabetes mellitus were observed for periods of many months as to their response to continued…