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Phenformin

Known as: Imidodicarbonimidic diamide, N-(2-phenylethyl)-, Phenforminum, Fenformina 
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (3)

4-hydroxyphenforminphenethylguanidinetolbutaphen
HypoglycemiaIn BloodPhenformin Hydrochlorideagonists

Broader (2)

Hypoglycemic Agentsorganic nitrogen compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.
2009
2009
Phenformin and ethyloestrenol in recurrent venous thrombosis.
Altogether 75 patients, 60 of whom had recurrent idiopathic deep venous thrombosis, 10 recurrent superficial thrombophlebitis and… 
Highly Cited
2007
Highly Cited
2007
Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.
AMP-activated protein kinase (AMPK) acts as a cellular energy sensor: it responds to an increase in AMP concentration ([AMP]) or… 
Highly Cited
2004
Highly Cited
2004
Molecularly imprinted solid-phase extraction for the screening of antihyperglycemic biguanides.
Highly Cited
1979
Highly Cited
1979
Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system
1973
1973
Mode of action of hypoglycemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liver.
Abstract In isolated perfused rat liver, phenethylbiguanide inhibits the rate of glucose production from both lactate and… 
Highly Cited
1968
Highly Cited
1968
INHIBITION OF HEPATIC GLUCONEOGENESIS IN GUINEA PIG BY PHENFORMIN
The mechanism of action of phenformin has not yet been fully elucidated. Tyberghein and Williams' have presented evidence that… 
Highly Cited
1967
Highly Cited
1967
Fibrinolytic effects of diguanides plus ethyloestrenol in occlusive vascular disease.
Highly Cited
1963
Highly Cited
1963
The Effects of Guanidine and Alkylguanidines on the Energy Transfer Reactions of Mitochondria
Considerable attention has been focused on the biological activity of guanidine derivatives from two main directions. Ever since… 
Highly Cited
1958
Highly Cited
1958
A site of action of phenethylbiguanide, a hypoglycemic compound.
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