• Publications
  • Influence
[15] Isolation of liver or kidney mitochondria
TLDR
This chapter describes the isolation of liver or kidney mitochondria and the method for testing the quality of mitochondria, with the exception that the mitochondrial pellet need be washed only once. Expand
Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
TLDR
The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice, suggesting potential defects in female fertility and/or ovulation. Expand
Potassium-dependent increases in cytosolic pH stimulate metabolism and motility of mammalian sperm.
TLDR
Observations indicate that cytosolic pH plays a role in the regulation of motility and metabolism of mammalian sperm that is not mediated by cyclic AMP but that may be under control of a plasma membrane voltage-dependent proton channel. Expand
[37] Malic enzyme
Publisher Summary The chapter describes the isolation procedure, assay methods, and properties of malic enzyme. The specific activity of the crystalline malic enzyme isolated is 27-30 (micromolesExpand
A23187: a divalent cation ionophore.
  • P. Reed, H. Lardy
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 10 November 1972
TLDR
It is proposed that a cyclic, energy-dissipating flux of mitochondrial calcium accounts for uncoupling by A23187, whereas inhibition of ATPase and glutamate oxidation and increased potassium permeability of mitochondria result from antibiotic-mediated magnesium efflux. Expand
Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.
TLDR
In vivo evidence is provided of the need for functional AR in Sertoli cells to maintain normal spermatogenesis and testosterone production, and ensure normal male fertility. Expand
Ketone Bodies, Potential Therapeutic Uses
TLDR
Surprisingly, D‐ β‐hydroxybutyrate (abbreviated “βOHB”) may also provide a more efficient source of energy for brain per unit oxygen, supported by the same phenomenon noted in the isolated working perfused rat heart and in sperm. Expand
Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells
TLDR
Together, these PM-AR−/y mice provide in vivo evidence for the requirement of functional AR in peritubular myoid cells to maintain normal Sertoli cells function and peritubsic myoid cell contractility, thus ensuring normal spermatogenesis and sperm output. Expand
INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT.
TLDR
It is shown that there is a correlation between change in oxygen uptake by mitochondria and change in glycerol-P dehydrogenase activity in various thyroid states and that the enhanced activity probably results from the biosynthesis of new enzyme protein (4). Expand
Antioxidant enzyme systems in rat liver and skeletal muscle. Influences of selenium deficiency, chronic training, and acute exercise.
TLDR
The data indicate that antioxidant enzymes in liver and skeletal muscle are capable of adapting to selenium deficiency and exercise to minimize oxidative injury caused by free radicals. Expand
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