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Phase I/II Trial

Known as: 1-2, Trial Phase 1-2, Trial Phase 1/2 
A clinical research protocol designed to study the safety, dosage levels and response to new treatment. Phase I/II trials combine a Phase I and a… 
National Institutes of Health

Related topics

Related topics

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CDISC SDTM Trial Phase TerminologyClinical Data Interchange Standards Consortium Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Functional Interleukin-17 Receptor A is Expressed in the Central Nervous System and Upregulated in Experimental Autoimmune Encephalomyelitisa
Interleukin-17A (IL-17A) is founding member of a novel family of inflammatory cytokines that plays a critical role in the… 
Highly Cited
2004
Highly Cited
2004
Facile tailoring of film morphology and release properties using layer-by-layer assembly of thermoresponsive materials.
Layer-by-layer self-assembly was used to prepare thermoresponsive thin films of poly(N-isopropylacrylamide) (PNIPAAm) and poly… 
Review
2000
Review
2000
Three-dimensional intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: the University of California-San Francisco experience.
Highly Cited
1993
Highly Cited
1993
Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.
Transgenic mice carrying the Wnt-1 protooncogene modified for expression in mammary epithelial cells exhibit hyperplastic mammary… 
Highly Cited
1988
Highly Cited
1988
Bacterial exotoxins and endothelial permeability for water and albumin in vitro.
Effects of Staphylococcus aureus alpha-toxin and Pseudomonas aeruginosa cytotoxin on the permeability of an endothelial monolayer… 
Highly Cited
1987
Highly Cited
1987
Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III
Spinal cord neurons is dissociated cell culture were loaded with the calcium indicator arsenazo III using the whole-cell patch… 
Highly Cited
1985
Highly Cited
1985
Fast and sensitive detection of protein and DNA bands by treatment with potassium permanganate.
Highly Cited
1984
Highly Cited
1984
Resonance at the wrist demonstrated by the use of a torque motor: an instrumental analysis of muscle tone in man.
The resonance of the relaxed wrist for flexion‐extension movements in the horizontal plane has been investigated by using… 
Highly Cited
1975
Highly Cited
1975
Mass isolation and culture of rat kupffer cells
Collagenase perfusion of the liver followed by pronase treatment of the cell suspension thus obtained gave a quantitative… 
Highly Cited
1974
Highly Cited
1974
Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast.
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