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Perphenazine

Known as: Chlorpiprazine, Etaperazin, Perphénazine 
A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2… 
National Institutes of Health

Related topics

Related topics

38 relations
Adrenergic alpha-Antagonists [MoA]Amitriptyline / PerphenazineBlood Coagulation DisordersBone Marrow Diseases

Broader (5)

AntiemeticsAntipsychotic AgentsDopamine Antagonistsphenothiazine

Narrower (6)

EtrafonTrilafonTriptafenduo-tran

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study.
OBJECTIVE The relative effectiveness of newly started antipsychotic drugs for individuals with schizophrenia may depend on… 
Highly Cited
2006
Highly Cited
2006
Cost-effectiveness of second-generation antipsychotics and perphenazine in a randomized trial of treatment for chronic schizophrenia.
BACKGROUND Second-generation antipsychotics have largely replaced first-generation antipsychotics for the treatment of… 
Highly Cited
2006
Highly Cited
2006
Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.
Highly Cited
1999
Highly Cited
1999
Characterization of MK-801-induced behavior as a putative rat model of psychosis.
The objective of this study was to characterize the behavior induced by the N-methyl-D-aspartate receptor antagonist MK-801… 
Highly Cited
1998
Highly Cited
1998
The treatment of psychotic depression in later life: a comparison of pharmacotherapy and ECT
Objective. Response to combination pharmacotherapy and to electroconvulsive therapy (ECT) was evaluated in elderly patients with… 
Highly Cited
1984
Highly Cited
1984
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics.
Highly Cited
1981
Highly Cited
1981
Differential response to growth factor by rat mammary epithelium plated on different collagen substrata in serum-free medium.
Primary cultures of rat mammary epithelial cells proliferate and synthesize basement membrane collagen (type IV collagen) in a… 
Highly Cited
1980
Highly Cited
1980
Effects of inhibition of basement membrane collagen deposition on rat mammary gland development.
Highly Cited
1977
Highly Cited
1977
Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra
Highly Cited
1974
Highly Cited
1974
Studies on the mechanism of the dopamine-mediated inhibition of prolactin secretion.
A study of the in vitro effect of dopamine on the release of newly synthesized prolactin is reported. Pituitary glands of female… 
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