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Reliability and validity of Japanese version of the Mini‐International Neuropsychiatric Interview
TLDR
The results suggest that the MINI Japanese version succeeds in reliably and validly eliciting symptom criteria used in making DSM‐III‐R diagnoses, and can be performed in less than half the time required for the SCID‐P.
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.
Genetic variation in dysbindin (DTNBP1: dystrobrevin-binding protein 1) has recently been shown to be associated with schizophrenia. The dysbindin gene is located at chromosome 6p22.3, one of the
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
TLDR
An association study of the DISC1 gene with major depressive disorder and schizophrenia found that Cys704 allele of the Ser704Cys single-nucleotide polymorphism (SNP) was associated with an increased risk of developing MDD.
The Patient Health Questionnaire, Japanese Version: Validity According to the Mini-International Neuropsychiatric Interview–Plus
TLDR
Findings show very good concordance of the Japanese version of the Patient Health Questionnaire with the Japanese versions of the Mini-International Neuropsychiatric Interview–Plus.
Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro.
TLDR
Sertraline N-demethylation activities were detected in all cDNA-expressed CYP isoforms studied and that the contribution of any individual isoform does not exceed 40% of overall metabolism is suggested.
A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
TLDR
The results suggest that theBDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene.
Assessment of the Dexamethasone/CRH Test as a State-Dependent Marker for Hypothalamic-Pituitary-Adrenal (HPA) Axis Abnormalities in Major Depressive Episode: A Multicenter Study
TLDR
The results suggest that the DEX/CRH test is a sensitive state-dependent marker to monitor HPA axis abnormalities in major depressive episode during treatment, particularly in depressed patients who underwent ECT.
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