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Penicillin Amidase

Known as: Penicillin Acylase, Acylase, Penicillin, Penicillin amidohydrolase 
An enzyme catalyzing the hydrolysis of penicillin to penicin and a carboxylic acid anion. EC 3.5.1.11.
National Institutes of Health

Related topics

Related topics

12 relations
Cephalosporin AcylaseIn BloodProcess of secretionantagonists & inhibitors

Narrower (4)

Penicillin G AcylasePenicillin V Acylaseampicillin acylaseglutarylamidocephalosporanic acid acylase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Polymer nanoreactors shown to produce and release antibiotics locally.
We designed and prepared nanoreactors based on a poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-poly(2… 
Highly Cited
2009
Highly Cited
2009
Preparation and General Properties of Crystalline Penicillin Acylase from Escherichia coli ATCC 11 105
Highly Cited
2007
Highly Cited
2007
Permeation of 6-nitro-3-phenylacetamide benzoic acid (NIPAB) and hydrolysis by penicillin acylase immobilized in emulsion liquid membranes.
The effects of various commercial and model surfactants of different structure and hydrophilicity were studied on water-in-oil (w… 
Highly Cited
2004
Highly Cited
2004
Stabilization of Penicillin G Acylase from Escherichia coli: Site-Directed Mutagenesis of the Protein Surface To Increase Multipoint Covalent Attachment
ABSTRACT Three mutations on the penicillin acylase surface (increasing the number of Lys in a defined area) were performed. They… 
Highly Cited
2000
Highly Cited
2000
Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft.
Penicillin G acylase is a periplasmic protein, cytoplasmically expressed as a precursor polypeptide comprising a signal sequence… 
Highly Cited
1998
Highly Cited
1998
Ligand-induced conformational change in penicillin acylase.
The enzyme penicillin acylase (penicillin amidohydrolase EC 3.5.1. 11) catalyses the cleavage of the amide bond in the… 
Highly Cited
1990
Highly Cited
1990
Primary structure requirements for the maturation in vivo of penicillin acylase from Escherichia coli ATCC 11105.
The two constituent subunits of the enzyme penicillin acylase from Escherichia coli strain ATCC 11105 are derived from a single… 
Review
1990
Review
1990
Bioconversions in aqueous two-phase systems.
Highly Cited
1986
Highly Cited
1986
Identification of the major endogenous leukotriene metabolite in the bile of rats as N-acetyl leukotriene E4.
Highly Cited
1967
Highly Cited
1967
Purification and Properties of Penicillin Amidase from Bacillus megaterium
A penicillin amidase, obtained from the exogenous medium of a Bacillus megaterium culture, was purified approximately 96-fold by… 
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