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Pegylated Liposomal Nanoparticle-based Docetaxel Prodrug MNK-010

Known as: MNK-010, Pegylated Liposomal Docetaxel Prodrug MNK-010 
A formulation containing pegylated liposomal nanoparticles encapsulating a prodrug of the poorly water-soluble, second-generation taxane analog… 
National Institutes of Health

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Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

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2018
2018
Abstract 3524: Novel prodrugs of the glutamine antagonist 6-diazo-5-oxo-norleucine (DON) as treatment for malignant peripheral nerve sheath tumor
Neurofibromatosis Type I (NF1) is a heritable tumor predisposition syndrome in which up to 10% of patients develop malignant… 
2015
2015
Abstract 4400: Anti-tumor activity of liposomal docetaxel prodrug MNK-010 on PC3 human prostate xenografts in mice
The anti-mitotic taxanes are one of the most important families of anticancer drugs that have broad anti-tumor activity and are… 
2015
2015
Abstract CT230: A phase I first in human dose escalation trial of MNK-010 in subjects with advanced solid tumors
Background: Taxanes possess broad activity and are widely used for a variety of tumor types. Currently available formulations are… 
2015
2015
2312 Japanese phase I trial of hypoxia-activated prodrug evofosfamide (TH-302) as monotherapy in patients with solid tumors or in combination with gemcitabine in patients with advanced pancreatic…
2015
2015
Abstract 5516: Biodistribution of liposomal docetaxel prodrug MNK-010 in mice bearing A549 human NSCLC xenografts
The anti-mitotic taxanes belong to one of the most important families of anticancer drugs that have broad anti-tumor activity and… 
2013
2013
Antibody-directed double suicide gene therapy targeting of MUC1- positive leukemia cells in vitro and in vivo.
Our aim was to specifically transfer the cytosine deaminase (CD) and thymidine kinase (TK) genes into mucin 1 (MUC1)-positive… 
2010
2010
INCREASED EFFECTIVENESS OF GS-424020 A MUTUAL PRODRUG (MPD) CONTAINING SALMETEROL (SAL) AND DESISOBUTRYLCICLESONIDE (DESCIC) OVER ITS COMPONENTS IN THE SHEEP MODEL OF ASTHMA
2010
2010
A novel oncolytic adenovirus expressing Escherichia coli cytosine deaminase exhibits potent antitumor effect on human solid tumors.
PURPOSE This study aims to generate a more potent oncolytic adenovirus, Ad.hTERT-E1A/CMV-CD, which combines therapeutic gene and… 
Review
2009
Review
2009
Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies.
In recent years, a series of new and highly cytotoxic analogues of CC-1065 and the duocarmycins have been developed that can be… 
2008
2008
Cannabidiol prodrugs, compositions containing cannabidiol prodrugs and methods of use thereof
Described herein are cannabidiol prodrugs, methods for producing cannabidiol prodrugs, formulations containing cannabidiol… 
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