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Conversion of Proepithelin to Epithelins Roles of SLPI and Elastase in Host Defense and Wound Repair
TLDR
It is found that SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing, and supplying PEPi corrects the wound-healing defect in SLPI null mice. Expand
GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.
TLDR
Results suggest that the expression of the GS-X pump in both cisplatin-resistant and -sensitive cells is related to cell proliferation, and is suggested to contribute to vesicle-mediated excretion of GSH-drug conjugates from cells. Expand
Coordinated Induction of MRP/GS-X Pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells*
TLDR
Elevated expression of the MRP/GS-X pump and increased GSH biosynthesis together may be important factors in the cellular metabolism and disposition of cisplatin, alkylating agents, and heavy metals. Expand
Secretory leukocyte protease inhibitor prevents allergen-induced pulmonary responses in animal models of asthma.
TLDR
Results suggest that SLPI may provide therapeutic intervention against the pathophysiology of asthma and its underlying pathology and suggest that its effects on antigen-induced pulmonary responses were evaluated. Expand
The Effect of Secretory Leukocyte Protease Inhibitor (SLPI) on Ischemia/Reperfusion Injury in Cardiac Transplantation
TLDR
High intra‐graft concentrations of SLPI after administration of rSLPI were inversely correlated with protease levels early and TGF‐β expression late after reperfusion, indicating that SLPI plays a crucial role in early myocardial performance and postischemic inflammation after cardiac transplantation. Expand
Generation of nitric oxide by human neutrophils.
TLDR
It is demonstrated that human neutrophils are capable of generating nitric oxide through dissociation of nitrite anion production from the respiratory burst and lysosomal enzyme release. Expand
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with
TLDR
From this work, (Z)-5-[[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-methylene]-2-imino-4-thiazolidinone methanesulfonate salt was identified as a potent dual inhibitor of 5-lipoxygenase and cyclooxygen enzyme in the rat MFE model of inflammation. Expand
Candidacidal activity of myeloperoxidase: mechanisms of inhibitory influence of soluble cell wall mannan
TLDR
It is speculated that mannan solubilized in plasma and tissue fluid may interfere with neutrophil-mediated host defense against Candida infection and the possibility that free mannan may inhibit myeloperoxidase-mediated candidacidal activity. Expand
The cloning and characterization of a murine secretory leukocyte protease inhibitor cDNA.
TLDR
The cloning and characterization of murine SLPI is described, and significant differences between mSLPI and hSLPI are presented, notably a difference in expression pattern, and a structural difference in the protease binding site that correlates with a different in the spectrum of protease inhibiton. Expand
Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi.
TLDR
The results demonstrate the potential involvement of tryptase-mediated activation of proteinase-activated receptor-2 (PAR-2) in promoting airway hyperresponsiveness and demonstrate that the PAR-2-mediated response involves a neurogenic mechanism involving neuropeptide release. Expand
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