FAQ

Patched-2 Receptor

Known as: Patched 2 Receptor, Patched Receptor 2, Patched Homolog-2 
A patched receptor that may function redundantly with the PATCHED-1 RECEPTOR to modulate hedgehog signaling. It may also play a role in epidermal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2015
01220032015

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Related topics

6 relations
In Bloodagonistsantagonists & inhibitorsisolation & purification analysis
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PTCH2 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Patched-2 Receptor
physiological aspects
In Blood
PTCH2 protein, human
antagonists & inhibitors
agonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Vismodegib
In January 2012, vismodegib (Erivedge; Curis/Genentech), a small-molecule inhibitor of the Hedgehog signalling pathway, was… (More)
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2011
2011
Wnt and hedgehog gene pathway expression in serous ovarian cancer.
OBJECTIVE Ovarian cancer has very heterogeneous histological classification, and response to therapy of the same grade and type… (More)
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2011
2011
PTCH 2 ( patched homolog 2 ( Drosophila ) )
Receptor of Hedgehog ligands but lacks the strong capacity of PTCH1 to inhibit the signaling molecule Smoothened, which, through… (More)
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2010
2010
The sonic hedgehog pathway in chordoid tumours.
Sir: Compelling evidence now suggests that chordoma is derived from intraosseous notochordal remnants. Sonic hedgehog homologue… (More)
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Highly Cited
2009
Highly Cited
2009
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is… (More)
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2009
2009
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
BACKGROUND Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue… (More)
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2008
2008
Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden.
 
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2008
2008
Prenatal manifestation in a family affected by nevoid basal cell carcinoma syndrome.
We report here a three generations family with nevoid basal cell carcinoma syndrome (NBCCS) in which the diagnosis was made only… (More)
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2007
2007
Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases.
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Improving the management of rhabdomyosarcoma requires a… (More)
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2003
2003
Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors
Experimental mouse models are emerging as useful systems for the study of human brain tumors. Nuclear magnetic resonance imaging… (More)
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