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Paroxysmal nocturnal hemoglobinuria

Known as: Hemoglobinuria, Paroxysmal Nocturnal, Nocturnal Paroxysmal Hemoglobinuria, PNH 
A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic disorder with increased mortality and morbidity… 
Highly Cited
2008
Highly Cited
2008
The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated in patients with paroxysmal… 
Highly Cited
2007
Highly Cited
2007
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation… 
Highly Cited
2007
Highly Cited
2007
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal… 
Highly Cited
2006
Highly Cited
2006
BACKGROUND We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein… 
Review
2005
Review
2005
The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, marrow failure, and… 
Review
2005
Review
2005
These practice parameters are an update of the previously-published recommendations regarding the indications for polysomnography… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem… 
Highly Cited
1995
Highly Cited
1995
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and venous thrombosis, is…