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Paroxysmal nocturnal hemoglobinuria

Known as: Hemoglobinuria, Paroxysmal Nocturnal, Nocturnal Paroxysmal Hemoglobinuria, PNH 
A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated in patients with paroxysmal… 
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Highly Cited
2007
Highly Cited
2007
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation… 
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Highly Cited
2007
Highly Cited
2007
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal… 
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Highly Cited
2006
Highly Cited
2006
BACKGROUND We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein… 
Review
2005
Review
2005
The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, marrow failure, and… 
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Review
2005
Review
2005
These practice parameters are an update of the previously-published recommendations regarding the indications for polysomnography… 
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem… 
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Highly Cited
1999
Highly Cited
1999
In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A gene give rise to clonal populations of red… 
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and venous thrombosis, is…