Paroxysmal nocturnal hemoglobinuria

Known as: Hemoglobinuria, Paroxysmal Nocturnal, Nocturnal Paroxysmal Hemoglobinuria, PNH 
A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish… (More)
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis… (More)
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Highly Cited
2009
Highly Cited
2009
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal blood disorder that manifests with hemolytic anemia, bone marrow… (More)
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Highly Cited
2008
Highly Cited
2008
The natural history of paroxysmal nocturnal hemoglobinuria (PNH) clinical subcategories (classic PNH and aplastic anemia [AA]/PNH… (More)
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Highly Cited
2007
Highly Cited
2007
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation… (More)
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Highly Cited
2007
Highly Cited
2007
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem… (More)
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Highly Cited
1999
Highly Cited
1999
In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A gene give rise to clonal populations of red… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and venous thrombosis, is… (More)
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Highly Cited
1993
Highly Cited
1993
Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic disease characterized by abnormal blood cell populations in… (More)
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