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Paroxysmal nocturnal hemoglobinuria
Known as:
Hemoglobinuria, Paroxysmal Nocturnal
, Nocturnal Paroxysmal Hemoglobinuria
, PNH
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A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red or brownish…
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National Institutes of Health
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Related topics
Related topics
8 relations
Cold paroxysmal hemoglobinuria
Hematopoietic and Lymphoid Cell
Hematopoietic and Lymphoid Tissue
PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1
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Broader (2)
Hemoglobinuria
Hemoglobinuria, Paroxysmal
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.
R. Kelly
,
A. Hill
,
+7 authors
P. Hillmen
Blood
2010
Corpus ID: 206899754
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic disorder with increased mortality and morbidity…
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Highly Cited
2008
Highly Cited
2008
Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.
R. Brodsky
,
N. Young
,
+12 authors
P. Hillmen
Blood
2008
Corpus ID: 7304918
The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated in patients with paroxysmal…
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Highly Cited
2007
Highly Cited
2007
Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
R. Rother
,
S. Rollins
,
C. Mojcik
,
R. Brodsky
,
L. Bell
Nature Biotechnology
2007
Corpus ID: 22732675
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation…
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Highly Cited
2007
Highly Cited
2007
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
P. Hillmen
,
P. Muus
,
+13 authors
N. Young
Blood
2007
Corpus ID: 240852
Hemolysis and hemoglobinemia contribute to serious clinical sequelae in hemolytic disorders. In paroxysmal nocturnal…
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Highly Cited
2006
Highly Cited
2006
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
P. Hillmen
,
N. Young
,
+17 authors
L. Luzzatto
New England Journal of Medicine
2006
Corpus ID: 23829381
BACKGROUND We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein…
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Review
2005
Review
2005
Diagnosis and management of paroxysmal nocturnal hemoglobinuria.
C. Parker
,
M. Omine
,
+9 authors
G. Socié
Blood
2005
Corpus ID: 43471011
The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, marrow failure, and…
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Review
2005
Review
2005
Practice parameters for the indications for polysomnography and related procedures: an update for 2005.
C. Kushida
,
M. Littner
,
+12 authors
M. Wise
Sleep
2005
Corpus ID: 12205535
These practice parameters are an update of the previously-published recommendations regarding the indications for polysomnography…
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Highly Cited
2004
Highly Cited
2004
Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria.
P. Hillmen
,
C. Hall
,
+8 authors
R. Rother
New England Journal of Medicine
2004
Corpus ID: 27787366
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem…
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Highly Cited
1995
Highly Cited
1995
Natural history of paroxysmal nocturnal hemoglobinuria.
P. Hillmen
,
S. Lewis
,
M. Bessler
,
L. Luzzatto
,
J. Dacie
New England Journal of Medicine
1995
Corpus ID: 35578303
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH), which is characterized by intravascular hemolysis and venous thrombosis, is…
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Highly Cited
1993
Highly Cited
1993
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
J. Takeda
,
T. Miyata
,
+6 authors
T. Kinoshita
Cell
1993
Corpus ID: 22122559
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