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Pappalysin-1

Known as: Pregnancy-Associated Plasma Protein A, PAPP-A, EC 3.4.24.79 
Pappalysin-1 (1627 aa, ~181 kDa) is encoded by the human PAPPA gene. This protein is involved in the modulation of proteolysis.
National Institutes of Health

Related topics

Related topics

14 relations
Enzyme GeneHomo sapiensHydrolysisMetalloproteins

Broader (1)

PAPPA wt Allele

Papers overview

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2019
2019
Performance of first trimester maternal screening biomarkers pregnancy-associated plasma protein a (PAPP-A) and free beta human chorionic gonadotropin (FBHCG) on the Atellica® IM Analyzer
2015
2015
First‐Trimester 3‐Dimensional Power Doppler Placental Vascularization Indices From the Whole Placenta Versus the Placental Bed to Predict Preeclampsia
The purpose of this study was to compare the use of vascular indices derived from the whole placenta to those from the placental… 
2013
2013
A SENSITIVE TIME-RESOLVED FLUOROIMMUNOASSAY FOR DETERMINATION OF MEDIAN LEVELS OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A IN PREGNANT WOMEN IN CHINA
Pregnancy-associated plasma protein A (PAPP-A) is an important serum marker for first trimester screening. Its weekly median… 
2013
2013
Chapter 271 – Pappalysin-1 (Pregnancy-Associated Plasma Protein-A)
Highly Cited
2009
Highly Cited
2009
First‐Trimester Placental Volume and Vascularization Measured by 3‐Dimensional Power Doppler Sonography in Pregnancies With Low Serum Pregnancy‐Associated Plasma Protein A Levels
Objective. The purpose of this study was to investigate the first‐trimester placental volume and 3‐dimensional (3D) power Doppler… 
2009
2009
The impact of fetal gender on first trimester nuchal translucency and maternal serum free β‐hCG and PAPP‐A MoM in normal and trisomy 21 pregnancies
To investigate if fetal sex has an impact on 1st trimester combined screening for aenuploidy. 
2006
2006
Long term influence of regular intake of high dose n-3 fatty acids on CD40-ligand, pregnancy-associated plasma protein A and matrix metalloproteinase-9 following acute myocardial infarction
Summary Pregnancy-associated plasma protein A (PAPP-A) and matrix metalloproteinase 9 (MMP-9), both zinc-binding endopeptidases… 
2002
2002
Screening for trisomy 21 by maternal age, fetal nuchal translucency and maternal serum biochemistry at 11–14 weeks: a German multicenter study
Objective: To examine the effectiveness of screening for trisomy 21 by a combination of maternal age, fetal nuchal translucency… 
1999
1999
Identificación de las principales proteínas de unión a IGF (IGFBP) en tejidos de rata normal
En este trabajo se investigo la presencia de las principales proteinas de union a IGF-I en tejidos de rata y el tamano de los… 
Highly Cited
1995
Highly Cited
1995
Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells.
Smooth muscle cells (SMC) secrete insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) and an IGFBP-4 protease. The… 
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