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Pancreatic intraepithelial neoplasia

Known as: PanIN, Pancreatic Dysplasia 
A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts. It is a papillary or flat… 
National Institutes of Health

Related topics

Related topics

13 relations
Epithelial CellsEpitheliumExocrine pancreasGastrointestinal system

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer
Background Screening individuals at increased risk for pancreatic cancer (PC) detects early, potentially curable, pancreatic… 
Highly Cited
2010
Highly Cited
2010
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
Pancreatic cancer is one of the most fatal malignancies lacking effective therapies. Notch signaling is a key regulator of cell… 
Highly Cited
2009
Highly Cited
2009
Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia.
Primary cilia have been proposed to participate in the modulation of growth factor signaling pathways. In this study, we… 
Highly Cited
2008
Highly Cited
2008
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model comprised of putative precursor lesions… 
Highly Cited
2008
Highly Cited
2008
Update on pancreatic intraepithelial neoplasia.
Pancreatic intraepithelial neoplasia (PanIN) is a histologically well-defined precursor to invasive ductal adenocarcinoma of the… 
Highly Cited
2003
Highly Cited
2003
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Hedgehog signalling—an essential pathway during embryonic pancreatic development, the misregulation of which has been implicated… 
Highly Cited
2003
Highly Cited
2003
Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using a Pancreatic Intraepithelial Neoplasia Tissue Microarray
A multistep model for pancreatic adenocarcinoma has been proposed recently. In this model, well-defined, noninvasive ductal… 
Highly Cited
2003
Highly Cited
2003
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinoma ranks among the most lethal of human malignancies. Here, we assess the cooperative interactions… 
Highly Cited
2003
Highly Cited
2003
Clinicopathological Correlates of Pancreatic Intraepithelial Neoplasia: A Comparative Analysis of 82 Cases With and 152 Cases Without Pancreatic Ductal Adenocarcinoma
Pancreatic intraepithelial neoplasia is often associated with pancreatic ductal adenocarcinoma and is presumed to be its… 
Highly Cited
2002
Highly Cited
2002
Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia.
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