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Pancreatic Trypsin Secretory Inhibitor, Kazal

Known as: Pancreatic Secretory Trypsin Inhibitor, Kazal, TATI, SPINK1 
Pancreatic secretory trypsin inhibitor (79 aa, ~9 kDa) is encoded by the human SPINK1 gene. This protein plays a role in the modulation of trypsin… 
National Institutes of Health

Related topics

Related topics

7 relations
Genes, RegulatorRegulation of ProteolysisSPINK1 geneSPINK1 wt Allele

Broader (1)

Protein secretory trypsin inhibitor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis.
BACKGROUND & AIMS Idiopathic chronic pancreatitis (ICP) is a complex inflammatory disorder associated with multiple genetic and… 
Highly Cited
2009
Highly Cited
2009
Serine Protease Inhibitor Kazal Type 1 Promotes Proliferation of Pancreatic Cancer Cells through the Epidermal Growth Factor Receptor
Serine protease inhibitor, Kazal type 1 (SPINK1) is expressed not only in normal human pancreatic acinar cells but also in a… 
Highly Cited
2007
Highly Cited
2007
Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene
Variations in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor (PSTI)) are associated with chronic pancreatitis… 
Highly Cited
2006
Highly Cited
2006
Identification of CFTR, PRSS1, and SPINK1 Mutations in 381 Patients With Pancreatitis
Objectives: Chronic pancreatitis is a progressive inflammatory disorder leading to irreversible exocrine and/or endocrine… 
Review
2006
Review
2006
Biochemistry and Clinical Role of Trypsinogens and Pancreatic Secretory Trypsin Inhibitor
Trypsinogens and PSTI/TATI/SPINK1 are expressed, usually together, at high levels by the pancreas but also by many other normal… 
Highly Cited
2005
Highly Cited
2005
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice.
BACKGROUND & AIMS Serine protease inhibitor Kazal type 1 (SPINK1), which is structurally similar to epidermal growth factor, is… 
Review
2005
Review
2005
Genetics of Pancreatitis
There was some recent progress in the understanding of genetic risk factors in chronic pancreatitis. Due to this progress some of… 
Highly Cited
2005
Highly Cited
2005
Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice.
BACKGROUND & AIMS Endogenous trypsin inhibitors are believed to inhibit protease activity if trypsin becomes inadvertently… 
Highly Cited
2003
Highly Cited
2003
Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors*
Mesotrypsin is an enigmatic minor human trypsin isoform, which has been recognized for its peculiar resistance to natural trypsin… 
Highly Cited
1987
Highly Cited
1987
Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene.
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