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Pancreatic Trypsin Secretory Inhibitor, Kazal

Known as: Pancreatic Secretory Trypsin Inhibitor, Kazal, TATI, SPINK1 
Pancreatic secretory trypsin inhibitor (79 aa, ~9 kDa) is encoded by the human SPINK1 gene. This protein plays a role in the modulation of trypsin… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
SPINK1 is a therapeutic target in a subset of patients with SPINK1+/ETS− prostate cancer. Targeting Outside the Box Out-of-the… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND & AIMS Serine protease inhibitor Kazal type 1 (SPINK1), which is structurally similar to epidermal growth factor, is… Expand
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Highly Cited
2005
Highly Cited
2005
Background: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene—many of which cause cystic fibrosis… Expand
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Highly Cited
2003
Highly Cited
2003
Mesotrypsin is an enigmatic minor human trypsin isoform, which has been recognized for its peculiar resistance to natural trypsin… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND & AIMS Tropical pancreatitis, including tropical calcific pancreatitis and fibrocalculous pancreatic diabetes, is… Expand
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Highly Cited
2002
Highly Cited
2002
Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Gain-of-function trypsin mutations cause acute pancreatitis and chronic pancreatitis. Loss of trypsin inhibitor… Expand
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Highly Cited
1991
Highly Cited
1991
Data from various laboratories have indicated associations of various alleles determined by RFLPs within or adjacent to several… Expand
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Highly Cited
1990
Highly Cited
1990
One of female MZ twins presented with muscular dystrophy. Physical examination, creatine phosphokinase levels, and muscle biopsy… Expand
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Highly Cited
1989
Highly Cited
1989
A lacZ gene without a promoter, but containing its ribosome-binding site, was cloned next to the kanamycin-resistance (KmR) gene… Expand
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