SPINK1 gene

Known as: TATI, Serine Protease Inhibitor, Kazal Type 1 Gene, SPINK1 
This gene plays a role in the negative regulation of proteolysis.
National Institutes of Health

Papers overview

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2011
2011
BACKGROUND & AIMS Idiopathic chronic pancreatitis (ICP) is a complex inflammatory disorder associated with multiple genetic and… (More)
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2011
2011
OBJECTIVES We evaluated the frequencies and clinical consequences of mutations in the genes encoding cationic trypsinogen, serine… (More)
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Highly Cited
2008
Highly Cited
2008
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS… (More)
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2007
2007
BACKGROUND/AIMS Mutations of the SPINK1 gene encoding pancreatic secretory trypsin inhibitor have been identified in association… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVES Although autoimmune pancreatitis (AIP) has been recently recognized as a new disease entity of chronic pancreatitis… (More)
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2006
2006
OBJECTIVES Chronic pancreatitis is a progressive inflammatory disorder leading to irreversible exocrine and/or endocrine… (More)
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Highly Cited
2005
Highly Cited
2005
Understanding the distribution of genetic diversity within and among individuals, populations, species and gene pools is crucial… (More)
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Highly Cited
2002
Highly Cited
2002
Pancreatitis is a global health care problem with varied aetiologies. Alcoholism is responsible in the majority of patients while… (More)
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2002
2002
Fibrocalculous pancreatic diabetes (FCPD) is a secondary cause of diabetes due to chronic pancreatitis. Since the N34S variant of… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no… (More)
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