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Pancreatic Intraepithelial Neoplasia-1

Known as: Grade 1 Pancreatic Intraepithelial Neoplasia, Grade I Pancreatic Intraepithelial Neoplasia, PanIN-1 
A pancreatic intraepithelial neoplasia characterized by the presence of tall columnar cells that form flat or papillary, micropapillary, and basally… 
National Institutes of Health

Related topics

Related topics

13 relations
Epithelial CellsEpitheliumExocrine pancreasGastrointestinal system

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice
Significance KRAS is mutated in more than 90% of pancreatic adenocarcinoma (PDAC). Despite its well-known role in cancer… 
Review
2013
Review
2013
Incidentally Discovered Pancreatic Intraepithelial Neoplasia: What Is Its Clinical Significance?
PurposePancreatic intraepithelial neoplasia (PanIN) is a presumed precursor of pancreatic ductal adenocarcinoma (PDAC). We… 
Highly Cited
2012
Highly Cited
2012
Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL‐KrasG12D/+ mice
Pancreatic cancer is the one of most common causes of cancer deaths and has the worst prognosis. Clinical observational studies… 
2010
2010
The Epidermal Growth Factor Receptor Inhibitor Gefitinib Prevents the Progression of Pancreatic Lesions to Carcinoma in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy with a dismal prognosis. Developing novel… 
2009
2009
Widespread Activation of the DNA Damage Response in Human Pancreatic Intraepithelial Neoplasia
Pancreatic intraepithelial neoplasia (PanIN) lesions are the most common non-invasive precursors of pancreatic adenocarcinoma. We… 
Review
2008
Review
2008
Pancreatic Intraepithelial Neoplasia Revisited and Updated
Most pancreatic neoplasms are classified as ductal adenocarcinoma because they show a ductal phenotype, making a ductal origin… 
Highly Cited
2007
Highly Cited
2007
Class III β‐tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia
Aims:  Class III β‐tubulin (TUBB3) reduces microtubule stability and confers resistance to microtubule‐stabilizing taxanes… 
Highly Cited
2002
Highly Cited
2002
MUC4 expression increases progressively in pancreatic intraepithelial neoplasia.
Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic… 
Highly Cited
2002
Highly Cited
2002
Aberrant Methylation of the 5' CpG Island of TSLC1 Is Common in Pancreatic Ductal Adenocarcinoma and Is First Manifest in High-Grade PanINs
The recently identified tumor-suppressor gene TSLC1 on chromosome 11q23.2 is frequently inactivated in human non-small cell lung… 
2000
2000
Loss of Expression of Dpc 4 in Pancreatic Intraepithelial Neoplasia : Evidence That DPC 4 Inactivation Occurs Late in Neoplastic Progression 1
Infiltrating adenocarcinomas of the pancreas are believed to arise from histologically identifiable intraductal precursors… 
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