Loss of Expression of Dpc 4 in Pancreatic Intraepithelial Neoplasia : Evidence That DPC 4 Inactivation Occurs Late in Neoplastic Progression 1

@inproceedings{Wilentz2000LossOE,
  title={Loss of Expression of Dpc 4 in Pancreatic Intraepithelial Neoplasia : Evidence That DPC 4 Inactivation Occurs Late in Neoplastic Progression 1},
  author={Robb E. Wilentz and Christine A Iacobuzio-Donahue and Pedram Argani and Denis M. McCarthy and Jennifer L. Parsons and Charles J Yeo and Scott E. Kern and Ralph H. Hruban},
  year={2000}
}
Infiltrating adenocarcinomas of the pancreas are believed to arise from histologically identifiable intraductal precursors [pancreatic intraepithelial neoplasias (PanINs)] that undergo a series of architectural, cytological, and genetic changes. The role of DPC4tumor suppressor gene inactivation in this progression has not been defined. Immunohistochemistry for the Dpc4 protein in formalin-fixed, paraffin-embedded tissue is a sensitive and specific marker for DPC4 gene status, providing a tool… CONTINUE READING

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