FAQ

Paired Mesoderm Homeobox Protein 2B

Known as: PHOX2B Homeodomain Protein, Paired-Like Homeobox 2B, Neuroblastoma Phox 
Paired mesoderm homeobox protein 2B (314 aa, ~32 kDa) is encoded by the human PHOX2B gene. This protein plays a role in the regulation of gene… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
01219992017

Related topics

Related topics

8 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsPHOX2B gene
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Related mentions per year

Related mentions per year

1962-2018
1960198020002020
Paired Mesoderm Homeobox Protein 2B
dna binding
Genes, Regulator
Transcriptional Regulation
DNA-Binding Proteins
Homeodomain Proteins

Papers overview

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2017
2017
RT-qPCR for PHOX2B mRNA is a highly specific and sensitive method to assess neuroblastoma minimal residual disease in testicular tissue
Neuroblastoma (NB) is the most common type of extracranial solid tumor in children with a high prevalence in toddlers. For… (More)
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2012
2012
Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression.
The most common forms of neurocristopathy in the autonomic nervous system are Hirschsprung disease (HSCR), resulting in… (More)
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2010
2010
Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma
  • de Pontual Lo, Trochet Delphine, +12 authors Amiel Jeanne
  • 2010
Neuroblastoma (NB), an embryonic tumour originating from neural crest cells, is one of the most common solid tumours in childhood… (More)
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2010
2010
Title Transcriptional regulation of RET by Nkx 2 - 1 , Phox 2 b , Sox 10 , andPax 3
The rearranged during transfection (RET) gene encodes a single-pass receptor whose proper expression and function are essential… (More)
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2009
2009
Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3.
BACKGROUND The rearranged during transfection (RET) gene encodes a single-pass receptor whose proper expression and function are… (More)
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2007
2007
Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma.
Neuroblastoma (NB), an embryonic tumour originating from neural crest cells, is one of the most common solid tumours in childhood… (More)
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Review
2007
Review
2007
Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population.
Hirschsprung’s disease (OMIM 142623) is a complex congenital disorder characterised by the absence of ganglion cells of the… (More)
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2005
2005
Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital central hypoventilation syndrome.
Congenital central hypoventilation syndrome (CCHS) is a rare neurocristopathy characterized by absence of adequate autonomic… (More)
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2000
2000
Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription.
The homeodomain transcription factors Arix/Phox2a and NBPhox/Phox2b play a role in the specification of the noradrenergic… (More)
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1999
1999
Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation…
Homeodomain proteins play essential roles in basic processes during embryogenesis and development. NBPhox, a vertebrate paired… (More)
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