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Paired Mesoderm Homeobox Protein 2B

Known as: PHOX2B Homeodomain Protein, Paired-Like Homeobox 2B, Neuroblastoma Phox 
Paired mesoderm homeobox protein 2B (314 aa, ~32 kDa) is encoded by the human PHOX2B gene. This protein plays a role in the regulation of gene… Expand
National Institutes of Health

Related topics

Related topics

8 relations
DNA-Binding ProteinsGenes, RegulatorHomeodomain ProteinsPHOX2B gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways
Taste and most sensory inputs required for the feedback regulation of digestive, respiratory, and cardiovascular organs are… Expand
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Highly Cited
2010
Highly Cited
2010
Neuroblastoma Phox2b Variants Stimulate Proliferation and Dedifferentiation of Immature Sympathetic Neurons
Neuroblastoma is a pediatric tumor that is thought to arise from autonomic precursors in the neural crest. Mutations in the… Expand
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Highly Cited
2008
Highly Cited
2008
CO2-Sensitive Preinspiratory Neurons of the Parafacial Respiratory Group Express Phox2b in the Neonatal Rat
Phox2b protein is a specific marker for neurons in the parafacial region of the ventral medulla, which are proposed to play a… Expand
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Highly Cited
2008
Highly Cited
2008
PHOX2B is a novel and specific marker for minimal residual disease testing in neuroblastoma.
PURPOSE Polymerase chain reaction (PCR)-based detection of minimal residual disease (MRD) in neuroblastoma can be used to monitor… Expand
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Highly Cited
2005
Highly Cited
2005
Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent
Zebrafish lacking functional sox10 have defects in non-ectomesenchymal neural crest derivatives including the enteric nervous… Expand
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Highly Cited
2005
Highly Cited
2005
Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation
The paralogous paired‐like homeobox genes Phox2a and Phox2b are involved in the development of specific neural subtypes in the… Expand
Review
2004
Review
2004
Germline PHOX2B mutation in hereditary neuroblastoma.
To the Editor: We read with interest the study by Trochet and colleagues (2004), published in the April 2004 issue of The… Expand
Highly Cited
2003
Highly Cited
2003
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome
Congenital central hypoventilation syndrome (CCHS or Ondine's curse; OMIM 209880) is a life-threatening disorder involving an… Expand
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Highly Cited
2000
Highly Cited
2000
The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity.
In the vertebrate neural tube, cell cycle exit of neuronal progenitors is accompanied by the expression of transcription factors… Expand
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Highly Cited
1997
Highly Cited
1997
Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis.
Recent evidence suggests that specific families of homeodomain transcription factors control the generation and survival of… Expand
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