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PX 478

Known as: L-Phenylalanine, 4-[Bis(2-chloroethyl)oxidoamino]-, Dihydrochloride; L-Phenylalanine, 4-[Bis(2-chloroethyl)oxidoamino]-, Hydrochloride (1:2), PX-478, (S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline Oxide Dihydrochloride 
An orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha… 
National Institutes of Health

Related topics

Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

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2020
2020
Effects and Mechanism of Action of PX-478 in Oxygen-Induced Retinopathy in Mice
Importance: Retinopathy of prematurity (ROP) is an important risk factor for blindness in children due to neovascularization (NV… 
2019
2019
Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
[This corrects the article DOI: 10.18632/oncotarget.2948.]. 
2018
2018
Role of Micrornas in Impaired Gut Permeability Following Ethanol and Burn Injury
Ethanol remains a major confounder in the pathology associated with burn injury. Experimental studies have widely linked these… 
2018
2018
OR-026 Exercise induces HIF-1α redistribution in the small intestine
Objective Intestinal epithelial cells are positioned between an anaerobic lumen and a highly metabolic lamina propria, affected… 
2017
2017
Stage-Specific Effects of Hypoxia on Interstitial Lung Disease
Interstitial lung disease (ILD) comprises a group of lung diseases principally affecting the pulmonary interstitium, for example… 
2017
2017
Alcohol intoxication accelerates aging: Assessment of biomarkers of healthy aging in alcohol consumers
2017
2017
Inhibition of hypoxia-inducible factor-1α by PX-478 as a potential targeted therapy in ESCC.
e14083Background: Hypoxia is a unique microenvironment in solid tumors, including ESCC. We aim to investigate the interaction… 
2010
2010
Abstract 3632: Addition of the HIF-1α inhibitor PX-478 enhances the therapeutic efficacy of EGFR inhibitors in an orthotopic human lung adenocarcinoma model
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Introduction: Multiple studies demonstrate that… 
2009
2009
PX-478, a Novel Small Molecule Inhibitor of Hypoxia Inducible Factor-1 (HIF-1) Downregulates HIF and Induces Cytotoxicity in Diffuse Large B Cell Lymphoma Cells.
Abstract 2713 Poster Board II-689 Introduction: HIF-1 is a transcription factor that serves as a master regulator of cellular… 
2009
2009
Preclinical Therapeutic Sequencing using a Dual-Tracer Multi-Animal DCE-MRI Platform
Introduction Dynamic contrast-enhanced (DCE)-MRI is a functional imaging method that is often used to quantify changes in tumor… 
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