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PTPRJ gene

Known as: DEP1, PTPRJ, PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, J 
This gene plays a role in the negative regulation of T cell receptor signaling.
National Institutes of Health

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Colon CarcinomaDephosphorylationHydrolysisPTPRJ protein, human

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PTPRJ wt Allele

Papers overview

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2019
2019
PTPRJ: a novel inherited thrombocytopenia gene.
In this issue of Blood , Marconi et al use a high-throughput exome-sequencing approach to identify 2 biallelic loss-of-function… 
2018
2018
A NEW FORM OF INHERITED THROMBOCYTOPENIA CAUSED BY LOSS-OF-FUNCTION MUTATIONS IN PTPRJ
1 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. 2 Department of Molecular Medicine… 
2017
2017
Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues.
BACKGROUND/AIM Molecular mechanisms of alterations in protein tyrosine phosphatases (PTPs) genes in cancer have been previously… 
2012
2012
MicroRNA-205 Involvement in Cutaneous Melanoma
Thesis (Master, Pathology & Molecular Medicine) -- Queen's University, 2012-07-09 12:32:35.235 
Highly Cited
2010
Highly Cited
2010
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers
PurposeWe investigated the association between incidence of various cancers and four single nucleotide polymorphisms (SNPs), two… 
2009
2009
The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization.
Regulation of receptor-type phosphatases can involve the formation of higher-order structures, but the exact role played in this… 
2008
2008
The structure of the 5′-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation
Analysis of the human protein-tyrosine phosphatase (PTP) PTPRJ mRNA detected three in-frame AUGs at the 5′-end (starting at nt… 
Highly Cited
2004
Highly Cited
2004
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis
We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic… 
1998
1998
CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation.
Following ligation of the TCR and costimulatory molecules such as CD28, T cells proliferate and secrete cytokines. Several other… 
1992
1992
The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression
Developmental and tissue-specific transcription from the Adh distal promoter is regulated in part by the Adh adult enhancer… 
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