Skip to search formSkip to main contentSkip to account menu

PTPRJ gene

Known as: DEP1, PTPRJ, PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, J 
This gene plays a role in the negative regulation of T cell receptor signaling.
National Institutes of Health

Related topics

Related topics

9 relations
Colon CarcinomaDephosphorylationHydrolysisPTPRJ protein, human

Narrower (1)

PTPRJ wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
G-protein βγ subunits determine grain size through interaction with MADS-domain transcription factors in rice
The simultaneous improvement of grain quality and yield of cereal crops is a major challenge for modern agriculture. Here we show… 
Highly Cited
2017
Highly Cited
2017
Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield
Achieving increased grain productivity has long been the overriding focus of cereal breeding programs. The ideotype approach has… 
2013
2013
Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli
PTPRJ/CD148 is a tyrosine phosphatase that has tumour suppressor-like activity. Quantitative PCR of various cells and tissues… 
2010
2010
Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.
Oncogenic Ras mutations render the protein constitutively active and promote tumorigenesis via chronic stimulation of effector… 
Highly Cited
2005
Highly Cited
2005
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer.
Human homologues of mouse cancer modifier genes may play a role in cancer risk and prognosis. A proportion of the familial risk… 
Highly Cited
2004
Highly Cited
2004
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis
We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic… 
Highly Cited
2003
Highly Cited
2003
A Mutant Receptor Tyrosine Phosphatase, CD148, Causes Defects in Vascular Development
ABSTRACT Vascularization defects in genetic recombinant mice have defined critical roles for a number of specific receptor… 
Highly Cited
2003
Highly Cited
2003
LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12–21
Recently, the gene PTPRJ (protein tyrosine phosphatase receptor type J) was identified as the candidate gene for the mouse colon… 
Highly Cited
2002
Highly Cited
2002
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers
Only a small proportion of cancers result from familial cancer syndromes with Mendelian inheritance. Nonfamilial, 'sporadic… 
1992
1992
The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression
Developmental and tissue-specific transcription from the Adh distal promoter is regulated in part by the Adh adult enhancer… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)