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The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic… Expand The p53 tumor suppressor restricts tumorigenesis through the transcriptional activation of target genes involved in cell-cycle… Expand High PRL‐3 expression had been reported to have close association with lymph node metastasis (LNM) of gastric cancer. However… Expand PRL-3 is a metastasis-associated phosphatase. We and others have shown that its overexpression increases cell motility and… Expand A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine… Expand Purpose: The PRL-3 phosphatase has been found expressed at higher levels in metastasis than in primary tumors of patients with… Expand The phosphatase of regenerating liver (PRL) family of phosphatases, consisting of PRL-1, PRL-2, and PRL-3, represents an… Expand Recent reports suggested that phosphatase of regenerating liver (PRL)-3 might be involved in colorectal carcinoma metastasis with… Expand Purpose To investigate PRL-3 protein expression in normal colorectal epithelia and colorectal cancers with monoclonal antibody… Expand PURPOSE
Expression of the PRL-3 tyrosine phosphatase is elevated in liver metastases derived from colorectal cancer (CRC). We… Expand