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PTN gene

Known as: HEPARIN-BINDING GROWTH FACTOR 8, NEURITE OUTGROWTH-PROMOTING FACTOR, HEPARIN-BINDING, PTN 
This gene plays a role in the regulation of cellular growth and proliferation. It is also involved in nervous tissue development.
National Institutes of Health

Related topics

Related topics

9 relations
Cell Proliferation Regulatory ProcessHomo sapiensIntercellular Communication ProcessNeurogenesis

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PTN wt Allele

Papers overview

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2007
2007
Activation of phospholipase C pathways by a synthetic chondroitin sulfate‐E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons
In dopaminergic neurons, chondroitin sulfate (CS) proteoglycans play important roles in neuronal development and regeneration… 
2005
2005
Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster
Midkine (MK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. To date, this family of… 
Highly Cited
2003
Highly Cited
2003
Heterogeneity of the Chondroitin Sulfate Portion of Phosphacan/6B4 Proteoglycan Regulates Its Binding Affinity for Pleiotrophin/Heparin Binding Growth-associated Molecule*
PTPζ is a receptor-type protein-tyrosine phosphatase that is synthesized as a chondroitin sulfate proteoglycan and uses… 
Highly Cited
2002
Highly Cited
2002
Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients.
PURPOSE Recently, we found that pleiotrophin (PTN) acts as a rate-limiting autocrine growth factor in pancreatic cancer cells… 
Highly Cited
1996
Highly Cited
1996
Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas.
Midkine (MK) is a growth factor that promotes neurite outgrowth and survival of neurons, and enhances the plasminogen activator… 
1994
1994
Localization of pleiotrophin and midkine in the postnatal developing cerebellum
Review
1993
Review
1993
Midkine (MK), the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation.
Using mouse teratocarcinoma system, we found a novel retinoic acid responsive gene. Midkine (MK), the product of the gene is a… 
Highly Cited
1992
Highly Cited
1992
MK: a pluripotential embryonic stem-cell-derived neuroregulatory factor.
MK is a gene encoding a secreted heparin-binding polypeptide originally isolated by differential screening for genes induced by… 
Highly Cited
1988
Highly Cited
1988
Nonpharmacologic factors in the development of posttreatment nausea with adjuvant chemotherapy for breast cancer
A prospective, longitudinal design was used to determine the role of nonpharmacologic factors in the development of posttreatment… 
Highly Cited
1981
Highly Cited
1981
IgA-specific helper activity of T alpha cells in human peripheral blood.
A subpopulation of human T lymphocytes that express receptors of immunoglobulin A (T alpha cells) was separated by a FACS using… 
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