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PTCH2 gene

Known as: Patched 2 Gene, PATCHED, DROSOPHILA, HOMOLOG OF, 2, patched 2 
This gene plays a role in intercellular communication, embryonic structure development, and in tumorigenesis.
National Institutes of Health

Papers overview

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2015
2015
Ptch1 and Ptch2 are highly conserved vertebrate homologs of Drosophila ptc, the receptor of the Hedgehog (Hh) signaling pathway… Expand
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2013
2013
Hedgehog (HH) signaling is essential for vertebrate and invertebrate embryogenesis. In Drosophila, feedback upregulation of the… Expand
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2013
2013
Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental defects and… Expand
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2012
2012
Background:The Hedgehog (Hh) signalling pathway functions as an organiser in embryonic development. Recent studies have shown… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Naevoid basal cell carcinoma syndrome (NBCCS) is a pleiotropic, autosomal dominant disease. Growing evidence suggests… Expand
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Highly Cited
2004
Highly Cited
2004
The human PTCH2 gene is highly similar to PTCH1, a tumour suppressor gene frequently mutated in basal cell carcinoma and several… Expand
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2000
2000
Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity… Expand
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Highly Cited
1999
Highly Cited
1999
Mutations of the human Patched gene ( PTCH ) have been identified in individuals with the nevoid basal cell carcinoma syndrome… Expand
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1999
1999
By a combination of cDNA library screening, rapid amplification of cDNA ends analysis, and BAC sequencing, a novel human patched… Expand
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Highly Cited
1998
Highly Cited
1998
The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the… Expand
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