PTCH2 gene

Known as: Patched 2 Gene, PATCHED, DROSOPHILA, HOMOLOG OF, 2, patched 2 
This gene plays a role in intercellular communication, embryonic structure development, and in tumorigenesis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2017
02419982017

Papers overview

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2014
2014
The Hedgehog (Hh) signaling response is regulated by the interaction of three key components that include the sonic hedgehog (Shh… (More)
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2014
2014
The Patched 1 (Ptch1) receptor has a pivotal role in inhibiting the activity of the Hedgehog (Hh) pathway and is therefore… (More)
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2013
2013
Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental defects and… (More)
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2013
2013
Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or as a sporadic lesion. Gene mutations and loss of… (More)
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2008
2008
BACKGROUND Naevoid basal cell carcinoma syndrome (NBCCS) is a pleiotropic, autosomal dominant disease. Growing evidence suggests… (More)
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2008
2008
OBJECTIVE To investigate alterations in PTCH2 in keratocystic odontogenic tumors (KCOT) associated with nevoid basal cell… (More)
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2006
2006
Hedgehog proteins are important in the development of the nervous system. As Desert hedgehog (Dhh) is involved in the development… (More)
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1999
1999
By a combination of cDNA library screening, rapid amplification of cDNA ends analysis, and BAC sequencing, a novel human patched… (More)
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1999
1999
Mutations of the human Patched gene ( PTCH ) have been identified in individuals with the nevoid basal cell carcinoma syndrome… (More)
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Highly Cited
1998
Highly Cited
1998
The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the… (More)
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