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PTCH2 gene

Known as: Patched 2 Gene, PATCHED, DROSOPHILA, HOMOLOG OF, 2, patched 2 
This gene plays a role in intercellular communication, embryonic structure development, and in tumorigenesis.
National Institutes of Health

Related topics

Related topics

8 relations
Basal cell carcinomaDesmoplastic MedulloblastomaIntercellular Communication ProcessLigand Binding

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PTCH2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Germline mutation PTCH2 1172-1173delCT in Chinese population with early-onset breast cancer.
e13049 Background: Early-onset breast cancer has more aggressive clinicopathological characteristics and worse prognosis. The… 
2019
2019
Hedgehog signalling network gene status analysis in paediatric intracranial germ cell tumours.
INTRODUCTION Germ cell tumours (GCTs) in the children comprise a group of tumours that originate from primordial germ cells but… 
2018
2018
Interaction of the primordial germ cell-specific protein C2EIP with PTCH2 directs differentiation of embryonic stem cells via HH signaling activation
Although many marker genes for germ cell differentiation have been identified, genes that specifically regulate primordial germ… 
2017
2017
Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype
Gorlin syndrome is a genetic disorder of autosomal dominant inheritance that predisposes the affected individual to a variety of… 
2017
2017
Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations
The sonic hedgehog (SHH) signaling pathway has been shown to play important roles in embryogenesis, cell proliferation as well as… 
2011
2011
PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas
Background  Basal cell carcinomas (BCCs) are the most frequent human cancer that results from malignant transformation of basal… 
Review
2011
Review
2011
PTCH2 (patched homolog 2 (Drosophila))
Review on PTCH2 (patched homolog 2 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is implicated. 
2009
2009
A Susceptibility Locus on 1 p 32 – 1 p 34 for Congenital Macrostomia in a Chinese Family and Identification of a Novel PTCH 2 Mutation
A Susceptibility Locus on 1p32–1p34 for Congenital Macrostomia in a Chinese Family and Identification of a Novel PTCH2 Mutation… 
2009
2009
[Studies on keratocystic odontogenic tumors].
Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic keratocysts) are aggressive, noninflammatory jaw lesions… 
2000
2000
Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.
Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity… 
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