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PTC-209

National Institutes of Health

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2 relations

Broader (2)

Heterocyclic Compounds, 2-RingThiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Fluorescence imaging of biochemical relationship between ubiquitinated histone 2A and Polycomb complex protein BMI1.
2019
2019
PTC-209 Anti-Cancer Effects Involved the Inhibition of STAT3 Phosphorylation
Introduction: Lung, breast, and colorectal cancers are the leading causes of cancer-related deaths despite many therapeutic… 
2018
2018
Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents.
Bmi-1 is overexpressed in colorectal cancer (CRC) and served as a novel therapeutic target for the treatment of CRC. A series of… 
2017
2017
BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells.
BACKGROUND/AIM B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is up-regulated in several cancers… 
2017
2017
A miR-200 c / 141-BMI 1 autoregulatory loop regulates oncogenic activity of BMI 1 in cancer cells
MicroRNAs (miRNAs) are known to function as oncomiRs or tumor suppressors and are important noncoding RNA regulators of… 
2017
2017
Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia : implications for leukemia therapy
2017
2017
Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy
Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by… 
2017
2017
Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma
Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing… 
2016
2016
A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells
MicroRNAs (miRNAs) are known to function as oncomiRs or tumor suppressors and are important noncoding RNA regulators of… 
2015
2015
Treatment of biliary tract cancer cells with polycomb repressive complex 1 inhibitor PTC-209 reduces putative cancer stem cell population and causes cell cycle arrest
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