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PSI 6130

Known as: PSI-6130, PSI6130 
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The Discovery of Sofosbuvir: A Liver-Targeted Nucleotide Prodrug for the Treatment and Cure of HCV
Over the last 15 years, an increase in knowledge of the structure, function, life cycle, and pathogenesis of hepatitis C virus… 
2017
2017
The Financialization of a Cure: A Political Economy of Biomedical Innovation, Pricing, and Public Health
  • V. Roy
  • 2017
  • Corpus ID: 158620988
The Financialization of a Cure: A Political Economy of Biomedical Innovation, Pricing, and Public Health Victor Roy Sofosbuvir… 
2013
2013
Patent battle lines drawn as sofosbuvir gains approval
hepatitis C virus (HCV) drug was approved by the US Food and Drug Administration on 6 December, the specialist antiviral company… 
2011
2011
Design,synthesis and conversion evaluation in rats of PSI-6130 prodrugs
Hepatitis C virus(HCV),is one of the major causes of cirrhosis,hepatocellular carcinoma.HCV infection affects 180 million people… 
2010
2010
Alone or in Combination with Pegylated Interferon-a 2 a and Ribavirin Prevents Hepatitis C Virus ( HCV ) Replication and Selection of Resistant Variants in HCV-Infected Patients
Introduction. RG7128 (prodrug of PSI-6130) shows potent antiviral efficacy in patients infected with hepatitis C virus (HCV… 
2009
2009
90 PRECLINICAL STUDIES OF ANA598 COMBINED WITH OTHER ANTI-HCV AGENTS DEMONSTRATE POTENTIAL OF COMBINATION TREATMENT
2008
2008
Combinations of 2'-C-Methylcytidine Analogues with Interferon-α2b and Triple Combination with Ribavirin in the Hepatitis C Virus Replicon System
Background: Hepatitis C virus (HCV) polymerase is an essential enzyme for HCV replication and has multiple inhibitor binding… 
2008
2008
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent…
beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an… 
2007
2007
Pharmacokinetics of the Antiviral Agent β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine in Rhesus Monkeys
ABSTRACT β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is an effective inhibitor of hepatitis C virus (HCV) replication… 
2007
2007
[590] INHIBITION OF HCV REPLICATION BY PSI-6130: MECHANISM OF BIOCHEMICAL ACTIVATION AND INHIBITION
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