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- Publications
- Influence
Do psychiatric inpatients know their rights? A re-audit on information given to inpatients at a London mental health trust about their rights and admission to hospital
- G. A. Lomax, F. Raphael, James Pagliero, Rupal A Patel
- Medicine
- Medicine, science, and the law
- 1 January 2012
This re-audit assessed whether wards at South West London and St Georges’ mental health trust (SWLSTG) met agreed standards regarding informing inpatients about their legal status in hospital and… Expand
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of…
- Y. Zhou, S. Webber, +17 authors L. Kirkovsky
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 February 2008
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure-activity relationships (SAR), metabolic stability, and… Expand
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-,…
- L. Li, Y. Zhou, +23 authors C. Kissinger
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 1 June 2008
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. Lead optimization led to the discovery of compound 3a, which displayed potent inhibitory… Expand
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and…
- Y. Zhou, L. Li, +15 authors M. Sergeeva
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 February 2008
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2-… Expand
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
- M. Sergeeva, Y. Zhou, +19 authors P. Dragovich
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 June 2008
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as potent inhibitors of genotype 1 HCV NS5B polymerase focusing on the optimization of their drug metabolism and pharmacokinetics (DMPK)… Expand
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones…
- P. Dragovich, Julie K. Blazel, +17 authors Y. Zhou
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 October 2008
The synthesis of 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones bearing 6-amino substituents as potent inhibitors of the HCV RNA-dependent RNA… Expand
Comparative Prevalence of Eating Disorders in Obsessive-Compulsive Disorder and Other Anxiety Disorders
- H. Tyagi, Rupal A Patel, F. Rughooputh, H. Abrahams, Andrew R. J. Watson, L. Drummond
- Psychology, Medicine
- Psychiatry journal
- 23 August 2015
Objective. The purpose of this study was to compare the prevalence of comorbid eating disorders in Obsessive-Compulsive Disorder (OCD) and other common anxiety disorders. Method. 179 patients from… Expand
90 PRECLINICAL STUDIES OF ANA598 COMBINED WITH OTHER ANTI-HCV AGENTS DEMONSTRATE POTENTIAL OF COMBINATION TREATMENT
- P. A. Thompson, Rupal A Patel, K. Steffy, J. Appleman
- Chemistry
- 1 April 2009
Background: ANA598 is a novel HCV non-nucleoside polymerase inhibitor currently in clinical development for the treatment of hepatitis C. Due to the high potential for developing resistance to any… Expand
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
- F. Ruebsam, S. Webber, +21 authors L. Kirkovsky
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 June 2008
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed… Expand
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
- F. Ruebsam, D. Murphy, +29 authors L. Kirkovsky
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 November 2009
A novel series of non-nucleoside small molecules containing a tricyclic dihydropyridinone structural motif was identified as potent HCV NS5B polymerase inhibitors. Driven by structure-based design… Expand
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