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PRSS1 protein, human

Known as: TRY1 protein, human, trypsinogen 1 protein, human, trypsin 1 protein, human 
Trypsin-1 (247 aa, ~27 kDa) is encoded by the human PRSS1 gene. This protein is involved in proteolysis.
National Institutes of Health

Related topics

Related topics

11 relations
DigestionEnzyme GeneExtracellular SpaceGastrointestinal system

Broader (1)

TRYPSIN

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Sampling the N-terminal proteome of human blood
The proteomes of blood plasma and serum represent a potential gold mine of biological and diagnostic information, but challenges… 
Highly Cited
2010
Highly Cited
2010
MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes.
Highly Cited
2006
Highly Cited
2006
A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.
BACKGROUND & AIMS Missense mutations in human cationic trypsinogen PRSS1 are frequently detected in patients with hereditary… 
Highly Cited
2006
Highly Cited
2006
Chymotrypsin C (Caldecrin) Stimulates Autoactivation of Human Cationic Trypsinogen*
Trypsin-mediated trypsinogen activation (autoactivation) facilitates digestive zymogen activation in the duodenum but may… 
Highly Cited
2005
Highly Cited
2005
Adhesion signaling by a novel mitotic substrate of src kinases
Src kinases are activated and relocalize to the cytoplasm during mitosis, but their mitotic function has remained elusive. We… 
Review
2001
Review
2001
Genetic Testing for Hereditary Pancreatitis: Guidelines for Indications, Counselling, Consent and Privacy Issues
The identification of point mutations in the cationic trypsinogen (PRSS1) gene that underlie hereditary pancreatitis (HP) has… 
Highly Cited
2000
Highly Cited
2000
Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates*
Membrane-type serine protease 1 (MT-SP1) was recently cloned, and we now report its biochemical characterization. MT-SP1 is… 
Highly Cited
2000
Highly Cited
2000
Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen.
Hereditary pancreatitis (HP), an autosomal dominant disorder, has been associated with mutations in the cationic trypsinogen gene… 
Highly Cited
1999
Highly Cited
1999
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.
Serine proteases of the chymotrypsin fold are of great interest because they provide detailed understanding of their enzymatic… 
Highly Cited
1998
Highly Cited
1998
Mutations of the cationic trypsinogen in hereditary pancreatitis
Hereditary pancreatitis (OMIM 167800) is thought to be associated with a mutation of the exon 3 of cationic trypsinogen (Nature… 
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