S. Coughlin

Publications227
h-index89
Citations31,748
Highly Influential Citations1,352
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Thrombin signalling and protease-activated receptors
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an… Expand
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  • 124
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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
We isolated a cDNA encoding a functional human thrombin receptor by direct expression cloning in Xenopus oocytes. mRNA encoding this receptor was detected in human platelets and vascular endothelial… Expand
  • 2,718
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A dual thrombin receptor system for platelet activation
Platelet-dependent arterial thrombosis triggers most heart attacks and strokes. Because the coagulation protease thrombin is the most potent activator of platelets, identification of the platelet… Expand
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Protease‐activated receptors in hemostasis, thrombosis and vascular biology
  • S. Coughlin
  • Biology, Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 1 August 2005
Summary.  The coagulation cascade and protease‐activated receptors (PARs) together provide an elegant mechanism that links mechanical information in the form of tissue injury to cellular responses.… Expand
  • 873
  • 69
Protease-activated receptor 3 is a second thrombin receptor in humans
Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated… Expand
  • 839
  • 63
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.
Because of the role of thrombin and platelets in myocardial infarction and other pathological processes, identifying and blocking the receptors by which thrombin activates platelets has been an… Expand
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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid organs, but the source(s) of extracellular S1P and whether S1P directly promotes egress are unknown. By using mice in… Expand
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PAR3 is a cofactor for PAR4 activation by thrombin
Identification of the mechanisms by which the coagulation protease thrombin activates platelets is critical for understanding haemostasis and thrombosis. Thrombin activates cells at least in part by… Expand
  • 506
  • 36
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Monocyte chemoattractant protein 1 (MCP-1) is a member of the chemokine family of cytokines that mediate leukocyte chemotaxis. The potent and specific activation of monocytes by MCP-1 may mediate the… Expand
  • 662
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Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.
Protease-activated receptor 2 (PAR2) is expressed by vascular endothelial cells and other cells in which its function and physiological activator(s) are unknown. Unlike PAR1, PAR3, and PAR4, PAR2 is… Expand
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  • 29
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