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PRPF18 gene

Known as: hPrp18, pre-mRNA processing factor 18, PRPF18 
National Institutes of Health

Related topics

Related topics

1 relation
PRPF4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
A human P spliceosome structure Splicing of some pre–messenger RNAs could be regulated by cell type–specific splicing factors… 
Highly Cited
2011
Highly Cited
2011
DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps.
The assembly of the spliceosome involves dynamic rearrangements of interactions between snRNAs, protein components, and the pre… 
Highly Cited
2009
Highly Cited
2009
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components
The spliceosome is a ribonucleoprotein machine that removes introns from pre-mRNA in a two-step reaction. To investigate the… 
Highly Cited
2002
Highly Cited
2002
How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.
Slu7 and Prp18 act in concert during the second step of yeast pre-mRNA splicing. Here we show that the 382-amino-acid Slu7… 
Highly Cited
2002
Highly Cited
2002
A cyclophilin functions in pre‐mRNA splicing
We report that the cyclophilin USA‐CyP is part of distinct complexes with two spliceosomal proteins and is involved in both steps… 
Highly Cited
1998
Highly Cited
1998
Human homologs of yeast Prp16 and Prp17 reveal conservation of the mechanism for catalytic step II of pre‐mRNA splicing
Pre‐mRNA splicing takes place in two catalytic steps. The second step is poorly understood, especially in mammals. In yeast, the… 
Highly Cited
1997
Highly Cited
1997
A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.
We have identified a human splicing factor required for the second step of pre-mRNA splicing. This new protein, hPrp18, is 30… 
Highly Cited
1997
Highly Cited
1997
Functional and physical interaction between the yeast splicing factors Slu7 and Prp18.
We show that the requirement for Prp18 during the second step of actin pre-mRNA splicing in vitro is dictated by the distance… 
Highly Cited
1993
Highly Cited
1993
Stages in the second reaction of pre-mRNA splicing: the final step is ATP independent.
We have analyzed pre-mRNA splicing in yeast extracts immunodepleted of the PRP18 protein. We find that while the first step of… 
Highly Cited
1993
Highly Cited
1993
A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae
The PRP18 gene, which had been identified in a screen for pre-mRNA splicing mutants in Saccharomyces cerevisiae, has been cloned… 
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