PRMT5 gene

Known as: JAK-BINDING PROTEIN 1, ICLN-BINDING PROTEIN, 72-KD, PROTEIN ARGININE METHYLTRANSFERASE 5 
This gene is involved in both histone methylation and the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular processes, including tumorigenesis… (More)
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Highly Cited
2011
Highly Cited
2011
The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While… (More)
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Review
2011
Review
2011
Arginine methylation governs important cellular processes that impact growth and proliferation, as well as differentiation and… (More)
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Highly Cited
2010
Highly Cited
2010
Cyclin D1 elicits transcriptional effects through inactivation of the retinoblastoma protein and direct association with… (More)
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2010
2010
Defining the molecular mechanisms underpinning fetal (gamma) globin gene silencing may provide strategies for reactivation of… (More)
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Highly Cited
2009
Highly Cited
2009
Mammalian gene silencing is established through methylation of histones and DNA, although the order in which these modifications… (More)
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Highly Cited
2007
Highly Cited
2007
Protein arginine methyltransferase PRMT5 interacts with human SWI/SNF complexes and methylates histones H3R8 and H4R3. To… (More)
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Highly Cited
2004
Highly Cited
2004
Protein arginine methyltransferases (PRMTs) have been implicated in transcriptional activation and repression, but their role in… (More)
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Highly Cited
2003
Highly Cited
2003
The role of hSWI/SNF complexes in transcriptional activation is well characterized; however, little is known about their function… (More)
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Highly Cited
2001
Highly Cited
2001
We have identified a new mammalian protein arginine N-methyltransferase, PRMT5, formerly designated Janus kinase-binding protein… (More)
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