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PRMT5 gene

Known as: JAK-BINDING PROTEIN 1, ICLN-BINDING PROTEIN, 72-KD, PROTEIN ARGININE METHYLTRANSFERASE 5 
This gene is involved in both histone methylation and the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
National Institutes of Health

Related topics

Related topics

4 relations
MethylationPRMT5 wt AlleleProtein Arginine N-Methyltransferase 5, HumanProtein methylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.
2017
2017
Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation
Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and… 
2016
2016
Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer.
Identification of novel gastric cancer (GC)-related molecules is necessary to improve management of patients with GC in both… 
2015
2015
PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival
Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia… 
2015
2015
Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations
Protein arginine methyltransferases (PRMTs) catalyze the transfer of the methyl group from S-adenosyl-l-methionine (AdoMet) to… 
2014
2014
PRMT5 is essential for the eIF4E-mediated 5'-cap dependent translation.
2012
2012
Protein arginine methyltransferase 5 is an essential component of the hypoxia-inducible factor 1 signaling pathway.
2009
2009
GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells.
2004
2004
Human PRMT5 Expression Is Enhanced during in vitro Tubule Formation and after in vivo Ischemic Injury in Renal Epithelial Cells
Background: The interactions between cells and the extracellular matrix (ECM) are important in the regulation of cell growth and… 
2003
2003
A protein methyl transferase, PRMT5, selectively blocks oncogenic ras-p21 mitogenic signal transduction.
A Janus-2 (JAK-2) binding protein, JBP1, has been found to function as an arginine methyl transferase and is now designated PRMT5… 
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