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Over the last decade, there has been a significant increase in average paternal age when the first child is conceived, either due… Expand Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two types of protamine: protamine 1 (P1… Expand We report the development of a multiplex reverse transcription-polymerase chain reaction (RT-PCR) method for the definitive… Expand Abstract Cytokinesis is incomplete in spermatogenic cells, and the descendants of each stem cell form a clonal syncytium. As a… Expand We have compared the relative proportion of protamine 1 (P1) and protamine 2 (P2) bound to DNA in the sperm of a variety of… Expand During the spermatid elongation stage of spermiogenesis approximately 85% of sperm nuclear histones are replaced by protamines… Expand Transition nuclear proteins (TPs), the major proteins found in chromatin of condensing spermatids, are believed to be important… Expand The nuclei of spermatozoa in all mammals examined so far contain P1 protamine. A second protamine variant, protamine P2, has to… Expand Protamines are small, arginine-rich proteins involved in the condensation of sperm chromatin. Using cDNA clones, we have isolated… Expand Transcriptionally active nuclear extracts were prepared from mouse testes to study the transcription of the testis-specific mouse… Expand