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PPP6C protein, human

Known as: PP6C, EC 3.1.3.16, Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit 
Serine/threonine-protein phosphatase 6 catalytic subunit (305 aa, ~35 kDa) is encoded by the human PPP6C gene. This protein plays a role in protein… 
National Institutes of Health

Related topics

Related topics

14 relations
Cytoplasmic matrixDephosphorylationEnzyme GeneEsterase Gene

Broader (1)

protein phosphatase 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy
Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a… 
2017
2017
Regulation of the PP2AC, PP4C, PP6C and alpha4 signalling axis in the myocardium : roles in calcium homeostasis and hypertrophy
Cardiac physiology and hypertrophy are regulated by the phosphorylation status of most proteins, which is controlled by the… 
2016
2016
The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
Highly Cited
2015
Highly Cited
2015
Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma
Melanoma-associated mutations in a phosphatase are associated with increased autophagy, a process that can enhance tumor… 
2014
2014
EXPRESSION OF TYPE 2A PROTEIN PHOSPHATASES IN CARDIAC HEALTH AND DISEASE
Cardiac physiology and hypertrophy is regulated by the phosphorylation status of many proteins, which is regulated (in part) by… 
2013
2013
PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition
Recent whole genome melanoma sequencing studies have identified recurrent mutations in the gene encoding the catalytic subunit of… 
2012
2012
Regulatory Subunit R 1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase *
Background: PP6c3 and SAPSR1 bind to DNA-PK and are required for DNA-PK activation following ionizing radiation. Results: R1… 
2011
2011
Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks
DNA double-strand breaks (DSBs) are among the most lethal lesions associated with genome stability which, when destabilized… 
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