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SDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich… Expand Significance PP1, a metal-dependent enzyme responsible for >50% of all dephosphorylation reactions, forms distinct holoenzymes… Expand During cell division, accurate chromosome segregation is tightly regulated by Polo-like kinase 1 (PLK1) and opposing activities… Expand Faithful chromosome segregation during mitosis is tightly regulated by opposing activities of Aurora B kinase and protein… Expand Protein phosphatase-1 (PP1) controls many processes in eukaryotic cells. Modulation of mitosis by reversing phosphorylation of… Expand BackgroundHow epithelial cells adopt their particular polarised forms is poorly understood. In a screen for genes regulating… Expand Protein Ser/Thr phosphatase-1 (PP1) associates with a host of proteins to form substrate-specific holoenzymes. Sds22 and… Expand We have recently characterized Ypi1 as an inhibitory subunit of yeast Glc7 PP1 protein phosphatase. In this work we demonstrate… Expand Abstract Testis- and sperm-specific protein phosphatase, PP1γ2, is a key enzyme regulating sperm function. Its activity decreases… Expand Serine/threonine phosphatase PP1gamma2 is a testis-specific protein phosphatase isoform in spermatozoa. This enzyme appears to… Expand