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PPIP5K2 gene

Known as: CFAP160, PPIP5K2, HISTIDINE ACID PHOSPHATASE DOMAIN-CONTAINING PROTEIN 1 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus
Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in the US. KC normally has its onset in… Expand
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2019
2019
Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.
Processing of substrates by enzymes can only be fully understood through their conformational dynamics; this is particularly true… Expand
2018
2018
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse
Autosomal recessive nonsyndromic hearing loss is a genetically heterogeneous disorder. Here, we report a severe-to-profound… Expand
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2017
2017
Effect of Interface Trap Charges on Performance Variation of Heterogeneous Gate Dielectric Junctionless-TFET
In this paper, we investigate the effect of interface trap charges on the variation of heterogeneous gate dielectric junctionless… Expand
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2017
2017
Impact of Interface Trap Charges on Performance of Electrically Doped Tunnel FET With Heterogeneous Gate Dielectric
In this paper, we investigate for the first time effect of positive (donor) and negative (acceptor) interface trap charges on the… Expand
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2015
2015
Identification of a functional nuclear translocation sequence in hPPIP5K2
BackgroundCells contain several inositol pyrophosphates (PP-InsPs; also known as diphosphoinositol polyphosphates), which play… Expand
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2014
2014
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery
Summary Diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) is one of the mammalian PPIP5K isoforms responsible for synthesis… Expand
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2014
2014
Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I… Expand
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2013
2013
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
We obtained detailed kinetic characteristics–stoichiometry, reaction rates, substrate affinities and equilibrium conditions–of… Expand
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Highly Cited
2007
Highly Cited
2007
Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress*
Mammalian cells utilize multiple signaling mechanisms to protect against the osmotic stress that accompanies plasma membrane ion… Expand
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