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Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
TLDR
It is reported here that synaptojanin 1-deficient mice exhibit neurological defects and die shortly after birth, providing genetic evidence for a crucial role of phosphoinositide metabolism in synaptic vesicle recycling. Expand
A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization
TLDR
It is reported here that SopB, a Salmonella inositol polyphosphatase delivered to the host cell by this secretion system, mediates actin cytoskeleton rearrangements and bacterial entry in a Cdc42‐dependent manner. Expand
Inositol phosphates and cell signaling: new views of InsP5 and InsP6.
TLDR
Interest in the idea that these polyphosphates play more dynamic roles is now increasing, following recent demonstrations that they are precursors of several inositol phosphates that turnover rapidly. Expand
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.
There is little information concerning the intracellular function of inositol 1,3,4,5,6-pentakis- and hexakisphosphate, despite their being the most abundant inositol polyphosphates. Current opinionsExpand
The Inositol Hexakisphosphate Kinase Family
TLDR
Synthesis of the diphosphorylated inositol phosphates is revealed to be more complex and interdependent than previously envisaged. Expand
How versatile are inositol phosphate kinases?
  • S. Shears
  • Biology, Medicine
  • The Biochemical journal
  • 15 January 2004
TLDR
It will be shown that catalytic promiscuity towards different inositol phosphates is not typically an evolutionary compromise, but instead is sometimes exploited to facilitate tight regulation of physiological processes. Expand
A novel context for the ‘MutT’ module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
TLDR
A rat hepatic diphosphoinositol polyphosphate phosphohydrolase (DIPP) is purified and revealed a ‘MutT’ domain, which in other contexts guards cellular integrity by dephosphorylating 8‐oxo‐dGTP, which causes AT to CG transversion mutations. Expand
Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP5 Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress*
TLDR
The purification from rat brain of a diphosphoinositol pentakisphosphate kinase (PPIP5K) that synthesizes (PP)2-InsP4 is described, which is likely to be important signaling enzymes. Expand
The versatility of inositol phosphates as cellular signals.
  • S. Shears
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 8 December 1998
TLDR
The evidence that inositol phosphates have evolved into a versatile family of second messengers is assessed. Expand
Structural Analysis and Detection of Biological Inositol Pyrophosphates Reveal That the Family of VIP/Diphosphoinositol Pentakisphosphate Kinases Are 1/3-Kinases*
TLDR
This study deployed a microscale metal dye detection protocol coupled to a high performance liquid chromatography system that was calibrated with synthetic and biologically synthesized standards of inositol pyrophosphates, and unequivocally determined that 1/3,5-(PP)2-IP4 is the isomeric structure of the bis-diphosphoinositol tetrakisphosphate that is synthesized by yeasts and mammals. Expand
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