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PPI 2458

Known as: PPI-2458, PPI2458 
A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine… 
National Institutes of Health

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3 relations

Broader (2)

Epoxy CompoundsValine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
The natural product fumagillin exhibits potent antiproliferative and antiangiogenic properties. The semisynthetic analog PPI-2458… 
2013
2013
Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
Semisynthetic analogues of fumagillin, 1, inhibit methionine aminopeptidase-2 (MetAP2) and have entered the clinic for the… 
2012
2012
Efecto de la administración de PPI-­2458 sobre los procesos de proliferación celular y apoptosis en un modelo in vitro de hepatocarcinoma = Effect of treatment with PPI-2458 on cell proliferation and…
2011
2011
PPI-2458 reduces joint destruction in chronic collagen-induced arthritis
2009
2009
Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458
Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458… 
2009
2009
Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
Inhibition of methionine aminopeptidase-2 (MetAP2) represents a novel approach to antiangiogenic therapy. We describe the… 
2008
2008
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
Abstract.Objective:To elucidate the role of methionine aminopeptidase type-2 (MetAP-2) in the clinical pathology of rheumatoid… 
2007
2007
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation… 
2007
2007
Gateways to clinical trials.
Agomelatine, AGRO-100, AIDSVAX gp120 B/E, alfimeprase, aliskiren fumarate, ALVAC vCP1452, alvocidib hydrochloride, ambrisentan… 
2006
2006
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically… 
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