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Methionine aminopeptidases (MetAPs), which remove methionine residue from newly synthesized polypeptide chains, are a class of… Expand OBJECTIVE
To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal… Expand Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458… Expand OBJECTIVE
To determine the disease-modifying activity and mechanism of action of the orally available methionine aminopeptidase… Expand The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation… Expand Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically… Expand Purpose: Fumagillin and related compounds have potent antiproliferative activity through inhibition of methionine aminopeptidase… Expand Angiogenesis inhibition, which has been extensively studied for the treatment of various malignancies, is beginning to emerge as… Expand The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we… Expand The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial… Expand