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PPI 2458

Known as: PPI-2458, PPI2458 
A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine… 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Methionine aminopeptidases (MetAPs), which remove methionine residue from newly synthesized polypeptide chains, are a class of… 
Highly Cited
2011
Highly Cited
2011
OBJECTIVE To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal… 
2009
2009
Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458… 
2007
2007
OBJECTIVE To determine the disease-modifying activity and mechanism of action of the orally available methionine aminopeptidase… 
2007
2007
Abstract.Objective:To elucidate the role of methionine aminopeptidase type-2 (MetAP-2) in the clinical pathology of rheumatoid… 
2006
2006
Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically… 
2006
2006
Purpose: Fumagillin and related compounds have potent antiproliferative activity through inhibition of methionine aminopeptidase… 
Review
2005
Review
2005
Angiogenesis inhibition, which has been extensively studied for the treatment of various malignancies, is beginning to emerge as… 
Highly Cited
2005
Highly Cited
2005
The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we… 
Highly Cited
2004
Highly Cited
2004
The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial…