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PPI 2458

Known as: PPI-2458, PPI2458 
A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
OBJECTIVE To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal… Expand
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2010
2010
OBJECTIVE To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and… Expand
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2009
2009
Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458… Expand
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2007
2007
OBJECTIVE To determine the disease-modifying activity and mechanism of action of the orally available methionine aminopeptidase… Expand
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2007
2007
Abstract.Objective:To elucidate the role of methionine aminopeptidase type-2 (MetAP-2) in the clinical pathology of rheumatoid… Expand
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2007
2007
The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation… Expand
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2006
2006
Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically… Expand
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2006
2006
PURPOSE Fumagillin and related compounds have potent antiproliferative activity through inhibition of methionine aminopeptidase-2… Expand
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2005
2005
The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we… Expand
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2004
2004
The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial… Expand
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