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PPI 2458

Known as: PPI-2458, PPI2458 
A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine… 
National Institutes of Health

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3 relations

Broader (2)

Epoxy CompoundsValine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity
The natural product fumagillin exhibits potent antiproliferative and antiangiogenic properties. The semisynthetic analog PPI-2458… 
Review
2012
Review
2012
The development of MetAP-2 inhibitors in cancer treatment.
Methionine aminopeptidases (MetAPs), which remove methionine residue from newly synthesized polypeptide chains, are a class of… 
2010
2010
Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis.
OBJECTIVE To determine whether blood vessel growth at the onset of resolving synovitis leads to its subsequent persistence and… 
2009
2009
Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458
Pannus formation, in both rheumatoid arthritis (RA) and collagen-induced arthritis (CIA), is angiogenesis-dependent. PPI-2458… 
2008
2008
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
Abstract.Objective:To elucidate the role of methionine aminopeptidase type-2 (MetAP-2) in the clinical pathology of rheumatoid… 
2007
2007
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition
The enzyme methionine aminopeptidase-2 (MetAP-2) is thought to play an important function in human endothelial cell proliferation… 
2006
2006
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
Over the past few decades, melanoma has shown the fastest growing incidence rate of all cancers. This malignancy is clinically… 
Review
2005
Review
2005
New antiangiogenic strategies for the treatment of proliferative synovitis
Angiogenesis inhibition, which has been extensively studied for the treatment of various malignancies, is beginning to emerge as… 
Highly Cited
2005
Highly Cited
2005
Methionine aminopeptidases type I and type II are essential to control cell proliferation
The dependence of cell growth on methionine aminopeptidase (MetAP) function in bacteria and yeast is firmly established. Here we… 
Highly Cited
2004
Highly Cited
2004
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
The hallmark of rheumatoid arthritis (RA) is the progressive destruction of articular joints, characterized by invasive synovial… 
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