PP242

Known as: 2-(4-Amino-1-isopropyl-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-1H-indol-5-ol, PP-242, mTOR Kinase Inhibitor PP242 
 
National Institutes of Health

Papers overview

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2014
2014
Although preclinical work with rapalogs suggests potential in the treatment of gastric cancer, they have been less successful… (More)
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Highly Cited
2013
Highly Cited
2013
Lysosome is a key subcellular organelle in the execution of the autophagic process and at present little is known whether… (More)
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Highly Cited
2012
Highly Cited
2012
Metformin has been reported to lower cancer incidence among type II diabetics. Metformin exhibits antiproliferative and… (More)
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2012
2012
The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of… (More)
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2012
2012
Activation of PI3-K-AKT and ERK pathways is a complication of mTOR inhibitor therapy. Newer mTOR inhibitors (like pp242) can… (More)
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Highly Cited
2011
Highly Cited
2011
The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in breast cancers due to frequent mutations in PIK3CA… (More)
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Highly Cited
2011
Highly Cited
2011
Reprogramming of somatic cells to a pluripotent state was first accomplished using retroviral vectors for transient expression of… (More)
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Highly Cited
2010
Highly Cited
2010
Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions… (More)
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Highly Cited
2010
Highly Cited
2010
We genetically dissect the contribution of the most prominent downstream translational components of mTOR signaling toward Akt… (More)
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Highly Cited
2009
Highly Cited
2009
The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These… (More)
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