PON1 gene

Known as: PARAOXONASE, PLASMA, ESTERASE A, PON1 
This gene plays a role in the metabolism of organophosphates, lactones and aromatic carboxylic acid esters.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
CONTEXT Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective properties. The relationship between PON1… (More)
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Review
2005
Review
2005
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein (HDL). PON1 hydrolyzes several… (More)
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Highly Cited
2005
Highly Cited
2005
The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural… (More)
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Highly Cited
2005
Highly Cited
2005
PON1 is the best-studied member of a family of enzymes called serum paraoxonases, or PONs, identified in mammals (including… (More)
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Highly Cited
2003
Highly Cited
2003
Human serum paraoxonase (PON1), an HDL-associated esterase, protects lipoproteins against oxidation, probably by hydrolyzing… (More)
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Highly Cited
2001
Highly Cited
2001
Human HDL-associated paraoxonase (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces oxidation of LDLs… (More)
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Highly Cited
2000
Highly Cited
2000
The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Human serum paraoxonase (PON1) exists in two polymorphic forms: one that differs in the amino acid at position 192… (More)
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Highly Cited
2000
Highly Cited
2000
It is well established that human serum paraoxonase (PON1) catalyzes the hydrolysis of organophosphate insecticides and nerve… (More)
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Highly Cited
1996
Highly Cited
1996
A physiological role for paraoxonase (PON1) is still uncertain, but it catalyzes the hydrolysis of toxic organophosphates… (More)
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