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POLD1 gene

Known as: POLD1, CDC2 homolog (S. cerevisiae), POLYMERASE (DNA-DIRECTED), DELTA 1, CATALYTIC SUBUNIT 
This gene is involved in DNA replication and proofreading.
National Institutes of Health

Related topics

Related topics

8 relations
DNA Polymerase Delta Catalytic SubunitDNA Polymerase IIIDNA ReplicationDNA Replication Proofreading

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers
Many suspected Lynch Syndrome (sLS) patients who lack mismatch repair (MMR) germline gene variants and MLH1 or MSH2… 
Highly Cited
2015
Highly Cited
2015
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome
Segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs of premature aging affecting more than one… 
Highly Cited
2013
Highly Cited
2013
Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers
Polymerases ϵ and δ are the main enzymes that replicate eukaryotic DNA. Accurate replication occurs through Watson–Crick base… 
Highly Cited
2013
Highly Cited
2013
CSF1R mutations link POLD and HDLS as a single disease entity
Objective: Pigmented orthochromatic leukodystrophy (POLD) and hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS… 
Highly Cited
2012
Highly Cited
2012
Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene, POLD1*
Background: PRMT7 symmetrically methylates histones H2A and H4, and modulates cellular response to DNA damage. Results: PRMT7… 
Highly Cited
2008
Highly Cited
2008
In vitro antioxidant and antigenotoxic potentials of myricetin-3-o-galactoside and myricetin-3-o-rhamnoside from Myrtus communis: modulation of expression of genes involved in cell defence system…
Highly Cited
1997
Highly Cited
1997
The Human POLD1 Gene
The promoter of the human POLD1 gene encoding the catalytic subunit of DNA polymerase δ is G/C-rich and does not contain a TATA… 
Highly Cited
1987
Highly Cited
1987
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
A human homologue of the cdc2 gene has been cloned by expressing a human cDNA library in fission yeast and selecting for clones… 
Highly Cited
1986
Highly Cited
1986
Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe
The cdc2+ gene of Schizosaccharomyces pombe is homologous to the CDC28 gene of Saccharomyces cerevisiae. Both genes share limited… 
Highly Cited
1986
Highly Cited
1986
The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function
SummaryA DNA fragment called suc1 has been found to rescue cells mutated in the cell cycle control gene cdc2 of the fission yeast… 
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